Uses of antimicrobial genes from microbial genome

Sorek, Rotem; Rubin, Edward M.

Uses of antimicrobial genes from microbial genome

Patent · Tue Aug 20 04:00:00 EDT 2013

OSTI ID:1093250

Sorek, Rotem; Rubin, Edward M.

We describe a method for mining microbial genomes to discover antimicrobial genes and proteins having broad spectrum of activity. Also described are antimicrobial genes and their expression products from various microbial genomes that were found using this method. The products of such genes can be used as antimicrobial agents or as tools for molecular biology.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,513,489

Application Number:: 12/519,350

OSTI ID:: 1093250

Country of Publication:: United States

Language:: English

References (34)

High-level secretion of functional green fluorescent protein from transgenic tobacco cell cultures: Characterization and sensing Su, Wei Wen; Guan, Peizhu; Bugos, Robert C. Biotechnology and Bioengineering, Vol. 85, Issue 6 https://doi.org/10.1002/bit.10916	journal	January 2004
Antimicrobial Peptides of Lactic Acid Bacteria: Mode of Action, Genetics and Biosynthesis Sablon, E.; Contreras, B.; Vandamme, E. New Products and New Areas of Bioprocess Engineering https://doi.org/10.1007/3-540-45564-7_2	book	January 2000
Applications of the bacteriocin, nisin Delves-Broughton, J.; Blackburn, P.; Evans, R. J. Antonie van Leeuwenhoek, Vol. 69, Issue 2 https://doi.org/10.1007/BF00399424	journal	February 1996
How many antibiotics are produced by the genus Streptomyces ? Watve, Milind; Tickoo, Rashmi; Jog, Maithili Archives of Microbiology, Vol. 176, Issue 5 https://doi.org/10.1007/s002030100345	journal	November 2001
1H, 13C and 15N resonance assignment of phage T4 endoribonuclease RegB Odaert, Benoît; Saïda, Fakhri; Bontems, François Biomolecular NMR Assignments, Vol. 1, Issue 1 https://doi.org/10.1007/s12104-007-9021-4	journal	July 2007
Improvements in protein secondary structure prediction by an enhanced neural network Kneller, D. G.; Cohen, F. E.; Langridge, R. Journal of Molecular Biology, Vol. 214, Issue 1 https://doi.org/10.1016/0022-2836(90)90154-E	journal	July 1990
[19] Rapid and efficient site-specific mutagenesis without phenotypic selection Kunkel, Thomas A.; Roberts, John D.; Zakour, Richard A. Methods in Enzymology, p. 367-382 https://doi.org/10.1016/0076-6879(87)54085-X	book	January 1987
Isolation and characterization of a novel class of plant antimicrobial peptides form Mirabilis jalapa L. seeds. Cammue, B. P.; De Bolle, M. F.; Terras, F. R. Journal of Biological Chemistry, Vol. 267, Issue 4 https://doi.org/10.1016/S0021-9258(18)45866-8	journal	February 1992
Basic local alignment search tool Altschul, Stephen F.; Gish, Warren; Miller, Webb Journal of Molecular Biology, Vol. 215, Issue 3, p. 403-410 https://doi.org/10.1016/S0022-2836(05)80360-2	journal	October 1990
The role of cationic antimicrobial peptides in innate host defences Hancock, Robert E. W.; Diamond, Gill Trends in Microbiology, Vol. 8, Issue 9 https://doi.org/10.1016/S0966-842X(00)01823-0	journal	September 2000
Phage abortive infection in lactococci: variations on a theme Chopin, Marie-Christine; Chopin, Alain; Bidnenko, Elena Current Opinion in Microbiology, Vol. 8, Issue 4 https://doi.org/10.1016/j.mib.2005.06.006	journal	August 2005
First structural investigation of the restriction ribonuclease RegB: NMR spectroscopic conditions, 13C/15N double-isotopic labelling and two-dimensional heteronuclear spectra Saı̈da, Fakhri; Odaert, Benoı̂t; Uzan, Marc Protein Expression and Purification, Vol. 34, Issue 1 https://doi.org/10.1016/j.pep.2003.11.002	journal	March 2004
Cloning and expression of a PR5-like protein from Arabidopsis: inhibition of fungal growth by bacterially expressed protein Hu, Xu; Reddy, A. S. N. Plant Molecular Biology, Vol. 34, Issue 6, p. 949-959 https://doi.org/10.1023/A:1005893119263	journal	January 1997
Use of the Genetically Engineered Agrobacterium Strain K1026 for Biological Control of Crown Gall Penyalver, Ramón; Vicedo, Begonya; López, María M. European Journal of Plant Pathology, Vol. 106, Issue 9, p. 801-810 https://doi.org/10.1023/A:1008785813757	journal	January 2000
A bacteriolytic agent that detects and kills Bacillus anthracis Schuch, Raymond; Nelson, Daniel; Fischetti, Vincent A. Nature, Vol. 418, Issue 6900 https://doi.org/10.1038/nature01026	journal	August 2002
Rapid and efficient site-specific mutagenesis without phenotypic selection. Kunkel, T. A. Proceedings of the National Academy of Sciences, Vol. 82, Issue 2, p. 488-492 https://doi.org/10.1073/pnas.82.2.488	journal	January 1985
Osmotin overexpression in potato delays development of disease symptoms. Liu, D.; Raghothama, K. G.; Hasegawa, P. M. Proceedings of the National Academy of Sciences, Vol. 91, Issue 5 https://doi.org/10.1073/pnas.91.5.1888	journal	March 1994
S1 Ribosomal Protein Functions in Translation Initiation and Ribonuclease RegB Activation Are Mediated by Similar RNA-Protein Interactions Aliprandi, Pascale; Sizun, Christina; Perez, Javier Journal of Biological Chemistry, Vol. 283, Issue 19 https://doi.org/10.1074/jbc.M707111200	journal	May 2008
Artemis: sequence visualization and annotation Rutherford, K.; Parkhill, J.; Crook, J. Bioinformatics, Vol. 16, Issue 10 https://doi.org/10.1093/bioinformatics/16.10.944	journal	October 2000
Mapping analysis of the Xylella fastidiosa genome Frohme, M. Nucleic Acids Research, Vol. 28, Issue 16 https://doi.org/10.1093/nar/28.16.3100	journal	August 2000
Fast algorithms for large-scale genome alignment and comparison Delcher, A. L. Nucleic Acids Research, Vol. 30, Issue 11 https://doi.org/10.1093/nar/30.11.2478	journal	June 2002
The sequences and activities of RegB endoribonucleases of T4-related bacteriophages Piesiniene, L. Nucleic Acids Research, Vol. 32, Issue 18 https://doi.org/10.1093/nar/gkh892	journal	October 2004
Machine learning approaches for the prediction of signal peptides and other protein sorting signals Nielsen, Henrik; Brunak, Søren; von Heijne, Gunnar Protein Engineering, Design and Selection, Vol. 12, Issue 1 https://doi.org/10.1093/protein/12.1.3	journal	January 1999
Spectral Profiling for the Simultaneous Observation of Four Distinct Fluorescent Proteins and Detection of Protein-Protein Interaction via Fluorescence Resonance Energy Transfer in Tobacco Leaf Nuclei Kato, Naohiro; Pontier, Dominique; Lam, Eric Plant Physiology, Vol. 129, Issue 3 https://doi.org/10.1104/pp.005496	journal	July 2002
Interactions between Plasma Membrane Aquaporins Modulate Their Water Channel Activity Fetter, Karolina; Van Wilder, Valérie; Moshelion, Menachem The Plant Cell, Vol. 16, Issue 1 https://doi.org/10.1105/tpc.017194	journal	December 2003
Post-transcriptional controls in bacteriophage T4: roles of the sequence-specific endoribonuclease RegB Sanson, Bénédicte; Uzan, Marc FEMS Microbiology Reviews, Vol. 17, Issue 1-2 https://doi.org/10.1111/j.1574-6976.1995.tb00196.x	journal	August 1995
Genome-Wide Experimental Determination of Barriers to Horizontal Gene Transfer Sorek, R.; Zhu, Y.; Creevey, C. J. Science, Vol. 318, Issue 5855 https://doi.org/10.1126/science.1147112	journal	November 2007
Bacteriophage T4 Genome Miller, E. S.; Kutter, E.; Mosig, G. Microbiology and Molecular Biology Reviews, Vol. 67, Issue 1 https://doi.org/10.1128/MMBR.67.1.86-156.2003	journal	March 2003
Bacteriocins: Evolution, Ecology, and Application Riley, Margaret A.; Wertz, John E. Annual Review of Microbiology, Vol. 56, Issue 1 https://doi.org/10.1146/annurev.micro.56.012302.161024	journal	October 2002
The N-myristoylated Rab-GTPase m-Rabmc is involved in post-Golgi trafficking events to the lytic vacuole in plant cells Bolte, Susanne; Brown, Spencer; Satiat-Jeunemaitre, Béatrice Journal of Cell Science, Vol. 117, Issue 6 https://doi.org/10.1242/jcs.00920	journal	February 2004
PCR-Assisted Contig Extension: Stepwise Strategy for Bacterial Genome Closure Carraro, D. M.; Camargo, A. A.; Salim, A. C. M. BioTechniques, Vol. 34, Issue 3 https://doi.org/10.2144/03343dd05	journal	March 2003
Genetically Engineered Bacteriocins and their Potential as the Next Generation of Antimicrobials Gillor, Osnat; Nigro, Lisa; Riley, Margaret Current Pharmaceutical Design, Vol. 11, Issue 8 https://doi.org/10.2174/1381612053381666	journal	March 2005
Expression of Highly Toxic Genes in E. coli: Special Strategies and Genetic Tools Saida, F.; Uzan, M.; Odaert, B. Current Protein and Peptide Science, Vol. 7, Issue 1 https://doi.org/10.2174/138920306775474095	journal	February 2006
Prevalence of Escherichia coli O157:H7 and Performance by Beef Feedlot Cattle Given Lactobacillus Direct-Fed Microbials† Brashears, M. M.; Galyean, M. L.; Loneragan, G. H. Journal of Food Protection, Vol. 66, Issue 5 https://doi.org/10.4315/0362-028X-66.5.748	journal	May 2003

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