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Mass spectrometric immunoassay

Patent ·
OSTI ID:1087876
; ;

Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

Research Organization:
Intrinsic Bioprobes, Inc. (Tempe, AZ)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-91ER61127
Assignee:
Intrinsic Bioprobes, Inc. (Tempe, AZ)
Patent Number(s):
8,486,713
Application Number:
13/421,633
OSTI ID:
1087876
Country of Publication:
United States
Language:
English

References (10)

Quantification of steroid conjugates using fast atom bombardment mass spectrometry journal October 1990
Purification and analysis of drug residues in urine samples by on-line immunoaffinity chromatography/high-performance liquid chromatography/continuous-flow fast-atom-bombardment mass spectrometry journal October 1993
Quantitative analysis of low molecular weight compounds of biological interest by matrix-assisted laser desorption ionization journal December 1993
Quantitative profiling of 6-ketoprostaglandin F1α, 2,3-dinor-6-ketoprostaglandin F1α, thromboxane B2 and 2,3-dinor-thromboxane B2 in human and rat urine by immunoaffinity extraction with gas chromatography—mass spectrometry journal January 1989
Immunoadsorption to improve gas chromatography/high-resolution mass spectrometry of estradiol-17 beta in plasma. journal April 1983
Epitope mapping of the gastrin-releasing peptide/anti-bombesin monoclonal antibody complex by proteolysis followed by matrix-assisted laser desorption ionization mass spectrometry journal September 1994
Direct Analysis of Affinity-Bound Analytes by MALDI/TOF MS journal September 1994
Mass Spectrometric Immunoassay journal April 1995
Quantitation of endogenous substance P by on-line microcolumn liquid chromatography/continuous-flow fast-atom bombardment mass spectrometry journal February 1989
Electrospray ionization mass spectrometry of phosphopeptides isolated by on-line immobilized metal-ion affinity chromatography journal August 1993

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES