Non-destructively shattered mesoporous silica for protein drug delivery

Journal Article · Mon Jul 15 04:00:00 EDT 2013 · Microporous and Mesoporous Materials, 175:157-160

DOI:https://doi.org/10.1016/j.micromeso.2013.03.022· OSTI ID:1083387

Lei, Chenghong; Chen, Baowei; Li, Xiaolin; Qi, Wen N.; Liu, Jun

Mesoporous silicas have been extensively used for entrapping small chemical molecules and biomacromolecules. We hypothesize that the loading density of biomacromlecules such as proteins in mesoporous silicas could be limited due to mesopore disorderness and depth because of some pore volume inaccessible. We innovatively shattered mesoporous silicas resulting in reduced particle sizes and improved intramesoporous structures in aqueous solution by a powerful sonication, where the mesoporous structures were still well maintained. The sonication-shattered mesoporous silicas can allow protein loading densities to be increased by more than 170%, demonstrating that significantly more mesoporous room of the silicas could become accessible for biomacromolecule loading after the sonication-shattering.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1083387
• Report Number(s): PNNL-SA-91369; KC0203020; 400412000
• Journal Information: Microporous and Mesoporous Materials, 175:157-160, Journal Name: Microporous and Mesoporous Materials, 175:157-160
• Country of Publication: United States
• Language: English