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Title: Biodegradable synthetic bone composites

Patent ·
OSTI ID:1082929

The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

Research Organization:
Univ. of California, Oakland, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
8,344,042
Application Number:
12/633,708
OSTI ID:
1082929
Country of Publication:
United States
Language:
English

References (17)

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Flexible Hydrogel-Based Functional Composite Materials patent-application November 2008
Polylactic Acid for Surgical Implants journal November 1966
Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same patent November 2002
Surgical Sutures patent January 1967
Bioactive glass coatings with hydroxyapatite and Bioglass® particles on Ti-based implants. 1. Processing journal January 2000
Osteogenic growth polypeptides identified from regenerating bone marrow patent October 1995
Bone Formation Agent and Method of Production patent-application November 2007
Investigation of the Poly( l -lactide)/Poly( d -lactide) Stereocomplex at the Air−Water Interface by Polarization Modulation Infrared Reflection Absorption Spectroscopy journal August 2001
Biodegradable poly(lactic acid) polymers journal May 1971
Bioactive glass coatings affect the behavior of osteoblast-like cells journal September 2007
Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers journal July 1993
Biodegradable polymers for use in surgery—polyglycolic/poly(actic acid) homo- and copolymers: 1 journal December 1979
Synthesis of a New PHEMA/PEO Enzymatically Biodegradable Hydrogel journal July 2006
Tissue Engineers Build New Bone journal September 2000
Hydroxyapatite-binding peptides for bone growth and inhibition patent September 2011
Injectable biodegradable temperature-responsive PLGA–PEG–PLGA copolymers: Synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels journal April 2005

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