Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making
Patent
·
OSTI ID:1082680
The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. ##STR00001## In particular, the invention relates N-substituted derivatives of 4-(hetero)aryl-1,2,5-oxadiazol-3-yl amines having the structural Formula (I) and (II), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. Meaning of R1 and R2 in the Formula (I) and (II) are defined in claim 1. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.
- Research Organization:
- U.S. Department of Energy, Washington, DC (United States)
- Sponsoring Organization:
- USDOE
- Assignee:
- U.S. Department of Energy (Washington, DC)
- Patent Number(s):
- 8,362,047
- Application Number:
- 12/822,243
- OSTI ID:
- 1082680
- Country of Publication:
- United States
- Language:
- English
Regulatory perspectives of Type II prodrug development and time-dependent toxicity management: Nonclinical Pharm/Tox analysis and the role of comparative toxicology
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journal | July 2007 |
High-Throughput Screening--Based Identification of Paramyxovirus Inhibitors
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journal | July 2008 |
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