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Imaging mass spectrometer with mass tags

Patent ·
OSTI ID:1082659
; ; ; ;
A method of analyzing biological material by exposing the biological material to a recognition element, that is coupled to a mass tag element, directing an ion beam of a mass spectrometer to the biological material, interrogating at least one region of interest area from the biological material and producing data, and distributing the data in plots.
Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-07NA27344
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA) ; Lawrence Berkeley National Laboratory (Berkeley, CA)
Patent Number(s):
8,362,415
Application Number:
12/788,146
OSTI ID:
1082659
Country of Publication:
United States
Language:
English

References (5)

Spatial Profiling with MALDI MS:  Distribution of Neuropeptides within Single Neurons journal September 2003
Chemical and Biological Differentiation of Three Human Breast Cancer Cell Types Using Time-of-Flight Secondary Ion Mass Spectrometry journal June 2006
The contributions of specific amino acid side chains to signal intensities of peptides in matrix-assisted laser desorption/ionization mass spectrometry journal April 2004
Single-cell MALDI: a new tool for direct peptide profiling journal April 2000
Discovering new neuropeptides using single-cell mass spectrometry journal September 2003

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