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Assay for vitamin B12 absorption and method of making labeled vitamin B12

Patent ·
OSTI ID:1055506
 [1];  [1];  [1];  [2];  [1];  [3];  [4]
  1. Davis, CA
  2. Elmacero, CA
  3. Silver Spring, MD
  4. Orinda, CA
+ Show Author Affiliations

The invention provides methods for labeling vitamin B12 with .sup.14C, .sup.13C, tritium, and deuterium. When radioisotopes are used, the invention provides for methods of labeling B12 with high specific activity. The invention also provides labeled vitamin B12 compositions made in accordance with the invention.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
W-7405-ENG-48
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
8,202,507
Application Number:
11/234,079
OSTI ID:
1055506
Country of Publication:
United States
Language:
English

References (10)

Biosynthesis of vitamin B12 in anaerobic bacteria. Experiments with Eubacterium limosum on the incorporation of D-[1-13C]erythrose and [13C]formate into the 5,6-dimethylbenzimidazole moiety journal March 1992
Purification and Characterization of CobT, the Nicotinate-mononucleotide:5,6-Dimethylbenzimidazole Phosphoribosyltransferase Enzyme from Salmonella typhimurium LT2 journal July 1997
Biosynthesis of cobalamin in Salmonella typhimurium : transformation of riboflavin into the 5,6-dimethylbenzimidazole moiety journal December 1998
Prospective evaluation of protein bound vitamin B 12 (cobalamin) malabsorption in the elderly using trout flesh labelled in vivo with 57 Co-cobalamin journal October 1997
Biosynthesis of vitamin B12 in anaerobic bacteria . Experiments with Eubacterium limosum on the transformation of 5-hydroxy-6-methyl-benzimidazole, its nucleoside, its cobamide, and of 5-hydroxybenzimidazolylcobamide in vitamin B12 journal June 1998
Biosynthesis of the 5,6-dimethylbenzimidazole moiety of vitamin B12 journal September 1969
Evaluation of Biosynthetic Pathways to δ-Aminolevulinic Acid in Propionibacterium shermanii Based on Biosynthesis of Vitamin B 12 from d -[1- 13 C]Glucose journal April 2000
Cobalamin and Folate Evaluation: Measurement of Methylmalonic Acid and Homocysteine vs Vitamin B12 and Folate journal August 2000
Biosynthesis of vitamin B12 in anaerobic bacteria. Transformation of 5-hydroxybenzimidazole and 5-hydroxy-6-methylbenzimidazole into 5,6-dimethylbenzimidazole in Eubacterium limosum journal November 1993
Autogenous regulation of ethanolamine utilization by a transcriptional activator of the eut operon in Salmonella typhimurium. journal October 1992

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Related Subjects

60 APPLIED LIFE SCIENCES