Whole-Genome Sequences of Thirteen Isolates of Borrelia burgdorferi

Journal Article · Tue Feb 01 04:00:00 EST 2011 · Journal of Bacteriology

DOI:https://doi.org/10.1128/JB.01158-10· OSTI ID:1044007

E, Schutzer S; Dunn, J; Fraser-Liggett, C M; Casjens, S R; Qiu, W -G; Mongodin, E F; Luft, B J

Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.

• Research Organization: BROOKHAVEN NATIONAL LABORATORY (BNL)
• Sponsoring Organization: NATIONAL INSTITUTE OF HEALTH
• DOE Contract Number: AC02-98CH10886
• OSTI ID: 1044007
• Report Number(s): BNL--94775-2012-JA; 400412000
• Journal Information: Journal of Bacteriology, Journal Name: Journal of Bacteriology Journal Issue: 4 Vol. 193; ISSN JOBAAY; ISSN 0021-9193
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DETECTION
DIAGNOSIS
DISEASES
PATHOGENESIS
PHENOTYPE
STRAINS
TICKS