skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Whole-Genome Sequences of Borrelia bissettii Borrelia valaisiana and Borrelia spielmanii

Abstract

It has been known for decades that human Lyme disease is caused by the three spirochete species Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii. Recently, Borrelia valaisiana, Borrelia spielmanii, and Borrelia bissettii have been associated with Lyme disease. We report the complete genome sequences of B. valaisiana VS116, B. spielmanii A14S, and B. bissettii DN127.

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
BROOKHAVEN NATIONAL LABORATORY (BNL)
Sponsoring Org.:
NATIONAL INSTITUTE OF HEALTH
OSTI Identifier:
1041624
Report Number(s):
BNL-96908-2012-JA
Journal ID: ISSN 0021-9193; JOBAAY; 400412000; TRN: US201212%%42
DOE Contract Number:
DE-AC02-98CH10886
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Bacteriology; Journal Volume: 194; Journal Issue: 2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; DISEASES; BNL; BACTERIA

Citation Formats

Schutzer S. E., Dunn J., Fraser-Liggett C. M., Qiu W.-G., Kraiczy P., Mongodin E. F., Luft B. J., and Casjens S. R.. Whole-Genome Sequences of Borrelia bissettii Borrelia valaisiana and Borrelia spielmanii. United States: N. p., 2012. Web. doi:10.1128/JB.06263-11.
Schutzer S. E., Dunn J., Fraser-Liggett C. M., Qiu W.-G., Kraiczy P., Mongodin E. F., Luft B. J., & Casjens S. R.. Whole-Genome Sequences of Borrelia bissettii Borrelia valaisiana and Borrelia spielmanii. United States. doi:10.1128/JB.06263-11.
Schutzer S. E., Dunn J., Fraser-Liggett C. M., Qiu W.-G., Kraiczy P., Mongodin E. F., Luft B. J., and Casjens S. R.. Sun . "Whole-Genome Sequences of Borrelia bissettii Borrelia valaisiana and Borrelia spielmanii". United States. doi:10.1128/JB.06263-11.
@article{osti_1041624,
title = {Whole-Genome Sequences of Borrelia bissettii Borrelia valaisiana and Borrelia spielmanii},
author = {Schutzer S. E. and Dunn J. and Fraser-Liggett C. M. and Qiu W.-G. and Kraiczy P. and Mongodin E. F. and Luft B. J. and Casjens S. R.},
abstractNote = {It has been known for decades that human Lyme disease is caused by the three spirochete species Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii. Recently, Borrelia valaisiana, Borrelia spielmanii, and Borrelia bissettii have been associated with Lyme disease. We report the complete genome sequences of B. valaisiana VS116, B. spielmanii A14S, and B. bissettii DN127.},
doi = {10.1128/JB.06263-11},
journal = {Journal of Bacteriology},
number = 2,
volume = 194,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 2012},
month = {Sun Jan 01 00:00:00 EST 2012}
}
  • Human Lyme disease is commonly caused by several species of spirochetes in the Borrelia genus. In Eurasia these species are largely Borrelia afzelii, B. garinii, B. burgdorferi, and B. bavariensis sp. nov. Whole-genome sequencing is an excellent tool for investigating and understanding the influence of bacterial diversity on the pathogenesis and etiology of Lyme disease. We report here the whole-genome sequences of four isolates from two of the Borrelia species that cause human Lyme disease, B. afzelii isolates ACA-1 and PKo and B. garinii isolates PBr and Far04.
  • Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.
  • Human Lyme disease is caused by a number of related Borrelia burgdorferi sensu lato species. We report here the complete genome sequence of Borrelia sp. isolate SV1 from Finland. This isolate is to date the closest known relative of B. burgdorferi sensu stricto, but it is sufficiently genetically distinct from that species that it and its close relatives warrant its candidacy for new-species status. We suggest that this isolate should be named 'Borrelia finlandensis.'