Overview of the Standing Operating Procedures (SOP) for the Development of Provisional Advisory Levels (PALs)

Journal Article · Thu Jan 01 04:00:00 EST 2009 · Inhalation Toxicology

DOI:https://doi.org/10.3109/08958370903202747· OSTI ID:1042728

Young, Robert ^[1]; Bast, Cheryl B ^[1]; Wood, Carol S ^[1]; Adeshina, Femi ^[2]; Ross, Robert Hord ^[1]

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1. ORNL
2. U.S. Environmental Protection Agency

Provisional Advisory Levels (PALs) are concentrations in air and drinking water for priority toxic chemicals. This article summarizes the Standing Operating Procedures (SOPs) currently in place for the data-driven development of chemical-specific PALs. To provide consistency and transparency, and to avoid faults of arbitrariness, SOPs were developed for guidance in deriving PAL values. The SOPs for PAL development focus on: 1) data acquisition and analysis, 2) identification of a chemical-specific critical effect, 3) selection of a quantitative point-of-departure (POD), 4) uncertainty analysis and adjustments, 5) exposure duration adjustment and extrapolation, 6) identification of special concerns and issues, and 7) verification, documentation and dissemination of PALs. To avoid uncompromising rigidity in deriving PAL values and to allow for incorporation of new or refined methodologies, the overall procedure is fluid and subject to modification. The purpose of this publication is to provide a summary of these SOPs.

• Research Organization: Oak Ridge National Laboratory (ORNL)
• Sponsoring Organization: ORNL work for others
• DOE Contract Number: AC05-00OR22725
• OSTI ID: 1042728
• Journal Information: Inhalation Toxicology, Journal Name: Inhalation Toxicology Journal Issue: s3 Vol. 21; ISSN INHTE5; ISSN 0895-8378
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
AIR
DATA ACQUISITION
DOCUMENTATION
DRINKING WATER
EXTRAPOLATION
TOXICITY
VERIFICATION