PROVISIONAL ADVISORY LEVELS (PALs) FOR ACRYLONITRILE

Journal Article · Thu Jan 01 04:00:00 EST 2009 · Inhalation Toxicology

DOI:https://doi.org/10.3109/08958370903202804· OSTI ID:1015678

Goldhaber, Susan ^[1]; Dorman, David ^[2]; Gardner, Donald ^[3]; Adeshina, Femi ^[4]; Ross, Robert Hord ^[5]

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1. Oak Ridge National Laboratory (ORNL)
2. College of Veterinary Medicine, North Carolina University
3. Inhalation Toxicology Associates
4. U.S. Environmental Protection Agency
5. ORNL

Application of PAL protocols was performed for acrylonitrile, as experimental data permitted. Human data were limited to inhalation exposures. The animal experimental data set for this chemical was robust for inhalation and oral studies, with the exception of appropriate data for inhalation 30-d, 90-d, and 2-yr PAL 3 values. PAL estimates were approved by the Expert Consultation Panel for Provisional Advisory Levels in October 2007. Oral 24-hr PALs for acrylonitrile are: PAL 1 = 7 mg/L; PAL 2 = 23 mg/L; and PAL 3 = 88 mg/L. Oral 30-d and 90-d PALs are: PAL 1 = 0.35 mg/L; PAL 2 = 7 mg/L; and PAL 3 = 17 mg/L. Oral 2-yr PALs are: PAL 1 = 0.35 mg/L; PAL 2 = 3.5 mg/L; and PAL 3 = 12 mg/L. Acrylonitrile inhalation PAL values for 24 hr exposure are: PAL 1 = 0.17 ppm; PAL 2 = 3.5 ppm; and PAL 3 = 5.1 ppm; the 30-d and 90-d inhalation exposure values are: PAL 1 = 0.15 ppm and PAL 2 = 0.60 ppm. The 2-yr inhalation values are: PAL 1 = 0.014 ppm and PAL 2 = 0.12 ppm. PAL 3 values for 30-d, 90-d, and 2-yr are not recommended due to insufficient data.

• Research Organization: Oak Ridge National Laboratory (ORNL)
• Sponsoring Organization: ORNL work for others
• DOE Contract Number: AC05-00OR22725
• OSTI ID: 1015678
• Journal Information: Inhalation Toxicology, Journal Name: Inhalation Toxicology Journal Issue: s3 Vol. 21; ISSN 0895-8378
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
ACRYLONITRILE
ANIMALS
INHALATION