Soluble Synthetic Analogs of Malaria Pigment: Structure of Mesohematin Anhydride [FeIII(MP-IX)]2 and Solution Interaction with Chloroquine

Journal Article · Fri Dec 30 23:00:00 EST 2011 · Angewandte Chemie International Edition

DOI:https://doi.org/10.1002/anie.201100910· OSTI ID:1041783

Bohle, D; Dodd, E; Kosar, A; Sharma, L; Stephens, P; Suarez, L; Tazoo, D

Changing the vinyl groups of hematin anhydride to either ethyl or hydrogen groups results in increased solubility (Por=porphyrin). Determination of the weak binding constants of the antimalarial drug chloroquine to dimers of these hematin anhydride analogues suggests that solution-phase heme/drug interactions alone are unlikely to be the origin of the action of the drug.

• Research Organization: BROOKHAVEN NATIONAL LABORATORY (BNL)
• Sponsoring Organization: USDOE SC OFFICE OF SCIENCE (SC)
• DOE Contract Number: AC02-98CH10886
• OSTI ID: 1041783
• Report Number(s): BNL--97461-2012-JA
• Journal Information: Angewandte Chemie International Edition, Journal Name: Angewandte Chemie International Edition Journal Issue: 27 Vol. 50; ISSN 1433-7851
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
ANHYDRIDES
DIMERS
DRUGS
HEME
INTERACTIONS
MALARIA
PIGMENTS
PORPHYRINS
SOLUBILITY
SOLUTIONS