PET imaging predicts future body weight and cocaine preference
Deficits in dopamine D2/D3 receptor (D2R/D3R) binding availability using PET imaging have been reported in obese humans and rodents. Similar deficits have been reported in cocaine-addicts and cocaine-exposed primates. We found that D2R/D3R binding availability negatively correlated with measures of body weight at the time of scan (ventral striatum), at 1 (ventral striatum) and 2 months (dorsal and ventral striatum) post scan in rats. Cocaine preference was negatively correlated with D2R/D3R binding availability 2 months (ventral striatum) post scan. Our findings suggest that inherent deficits in striatal D2R/D3R signaling are related to obesity and drug addiction susceptibility and that ventral and dorsal striatum serve dissociable roles in maintaining weight gain and cocaine preference. Measuring D2R/D3R binding availability provides a way for assessing susceptibility to weight gain and cocaine abuse in rodents and given the translational nature of PET imaging, potentially primates and humans.
- Research Organization:
- BROOKHAVEN NATIONAL LABORATORY (BNL)
- Sponsoring Organization:
- NATIONAL INSTITUTE ON ALCOHOL ABUSE & ALCOHOLISM (NIAAA)
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 1041614
- Report Number(s):
- BNL--96871-2012-JA; KP1602010
- Journal Information:
- Neuroimage, Journal Name: Neuroimage Journal Issue: 2 Vol. 59; ISSN 1053-8119
- Country of Publication:
- United States
- Language:
- English
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