Vitreal Ocygenation in Retinal Ischemia Reperfusion

Journal Article · Sat Jan 01 04:00:00 EST 2011 · Investigative Ophthalmology & Visual Science

DOI:https://doi.org/10.1167/iovs.09-4516· OSTI ID:1041097

Abdallab, Walid ^[1]; AmeriMD, Hossein ^[1]; Barron, Ernesto ^[2]; ChaderPhD, Gerald ^[1]; Greenbaum, Elias ^[3]; Hinton, David E ^[3]; Humayun, Mark S ^[1]

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1. Doheny Eye Institute, Los Angeles
2. Arnold and Mabel Beckman Macular Research Center, Doheny Eye Institute, Los Angeles
3. ORNL

PURPOSE. To study the feasibility of anterior vitreal oxygenation for the treatment of acute retinal ischemia. METHODS. Twenty rabbits were randomized into an oxygenation group, a sham treatment group, and a no treatment group. Baseline electroretinography (ERG) and preretinal oxygen (PO2) measurements were obtained 3 to 5 days before surgery. Intraocular pressure was raised to 100 mm Hg for 90 minutes and then normalized. The oxygenation group underwent vitreal oxygenation for 30 minutes using intravitreal electrodes. The sham treatment group received inactive electrodes for 30 minutes while there was no intervention for the no treatment group. Preretinal PO2 in the posterior vitreous was measured 30 minutes after intervention or 30 minutes after reperfusion (no treatment group) and on postoperative days (d) 3, 6, 9, and 12. On d14, rabbits underwent ERG and were euthanatized.

• Research Organization: Oak Ridge National Laboratory (ORNL)
• Sponsoring Organization: SC USDOE - Office of Science (SC)
• DOE Contract Number: AC05-00OR22725
• OSTI ID: 1041097
• Journal Information: Investigative Ophthalmology & Visual Science, Journal Name: Investigative Ophthalmology & Visual Science Journal Issue: 2 Vol. 52; ISSN 0146-0404; ISSN IOVSDA
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ELECTRODES
ISCHEMIA
OXYGEN
RABBITS
RETINA
SURGERY