Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry
We present the first results showing the ambient imaging of biological samples in their native environment using nanospray desorption ionization (nanoDESI) mass spectrometry. NanoDESI is an ambient pressure ionization technique that enables precise control of ionization of molecules from substrates. We demonstrate highly sensitive and robust analysis of tissue samples with high spatial resolution (<12 {mu}m) without sample preparation, which will be essential for applications in clinical diagnostics, drug discovery, molecular biology, and biochemistry.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1033045
- Report Number(s):
- PNNL-SA-79278; 39717; TRN: US201202%%547
- Journal Information:
- Analytical Chemistry, Vol. 84, Issue 1
- Country of Publication:
- United States
- Language:
- English
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