Studies of selenium and xenon in inductively coupled plasma mass spectrometry

Thesis/Dissertation · Wed Jul 27 04:00:00 EDT 1994

DOI:https://doi.org/10.2172/10190647· OSTI ID:10190647

Bricker, Tonya ^[1]

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1. Iowa State Univ., Ames, IA (United States)

Since its development, inductively coupled plasma mass spectrometry (ICP-MS) has been a widely used analytical technique. ICP-MS offers low detection limits, easy determination of isotope ratios, and simple mass spectra from analyte elements. ICP-MS has been successfully employed for many applications including geological, environmental, biological, metallurgical, food, medical, and industrial. One specific application important to many areas of study involves elemental speciation by using ICP-MS as an element specific detector interfaced to liquid chromatography. Elemental speciation information is important and cannot be obtained by atomic spectrometric methods alone which measure only the total concentration of the element present. Part 1 of this study describes the speciation of selenium in human serum by size exclusion chromatography (SEC) and detection by ICP-MS. Although ICP-MS has been widely sued, room for improvement still exists. Difficulties in ICP-MS include noise in the background, matrix effects, clogging of the sampling orifice with deposited solids, and spectral interference caused by polyatomic ions. Previous work has shown that the addition of xenon into the central channel of the ICP decreases polyatomic ion levels. In Part 2 of this work, a fundamental study involving the measurement of the excitation temperature is carried out to further understand xenon`s role in the reduction of polyatomic ions. 155 refs.

• Research Organization: Iowa State Univ. of Science and Technology, Ames, IA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: W-7405-ENG-82
• OSTI ID: 10190647
• Report Number(s): IS-T--1701; ON: DE95001676
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102
550200
59 BASIC BIOLOGICAL SCIENCES
BIOCHEMISTRY
BIOLOGICAL MATERIALS
CHEMICAL ANALYSIS
CHEMICAL AND SPECTRAL PROCEDURES
ENVIRONMENTAL MATERIALS
EXPERIMENTAL DATA
ICP MASS SPECTROSCOPY
IRON COMPOUNDS
PERFORMANCE
PROTEINS
SELENIUM
XENON