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Title: Application of a canine 238Pu dosimetry model to human bioassay data

Abstract

Associated with the use of 2238Pu in thermoelectric power sources for space probes and power supplies for cardiac devices is the potential for human exposure to 238Pu, primarily by inhalation. In the event of human internal exposure, a means is needed for assessing the level of intake and calculating radiation doses. Several bioassay/dosimetry models have been developed for 239Pu. However, results from studies with laboratory animals have indicated that the biokinetics, and therefore the descriptive models, of 238Pu are significantly different from those for 239Pu. A canine model accounting for these differences has been applied in this work to urinary excretion data from seven humans occupationally exposed to low levels of an insoluble 238Pu compound. The modified model provides a good description of the urinary excretion kinetics observed in the exposed humans. The modified model was also used to provide estimates of the initial intakes of 238Pu for the seven individuals; these estimates ranged from 4.5 nCi (170 Bq) to 87 nCi (3200 Bq). Autopsy data on the amount and distribution of 238Pu retained in the organs may be used in the future to validate or refute both these estimates and the assumptions used to formulate the human model. Modificationmore » of the human model to simulate an injection exposure to 239Pu gave patterns of retention in the organs and urinary excretion comparable to those seen previously in humans; further modification of the model using fecal data (unavailable for the subjects of this study) is indicated.« less

Authors:
 [1]
  1. Florida Univ., Gainesville, FL (United States)
Publication Date:
Research Org.:
Oak Ridge Associated Universities, Inc., TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
10189498
Report Number(s):
DOE/OR/00033-T540
ON: DE94000834
DOE Contract Number:  
AC05-76OR00033
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: TH: Thesis (M.S.); PBD: Aug 1991
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PLUTONIUM 238; DOSIMETRY; RADIATION DOSES; BIOLOGICAL MODELS; DOGS; MAN; SPECIES DIVERSITY; BIOASSAY; LUNGS; FECES; URINE; 560101; 560161; 560162; DOSIMETRY AND MONITORING; ANIMALS, PLANTS, MICROORGANISMS, AND CELLS

Citation Formats

Hickman, Jr., A. W. Application of a canine 238Pu dosimetry model to human bioassay data. United States: N. p., 1991. Web. doi:10.2172/10189498.
Hickman, Jr., A. W. Application of a canine 238Pu dosimetry model to human bioassay data. United States. https://doi.org/10.2172/10189498
Hickman, Jr., A. W. 1991. "Application of a canine 238Pu dosimetry model to human bioassay data". United States. https://doi.org/10.2172/10189498. https://www.osti.gov/servlets/purl/10189498.
@article{osti_10189498,
title = {Application of a canine 238Pu dosimetry model to human bioassay data},
author = {Hickman, Jr., A. W.},
abstractNote = {Associated with the use of 2238Pu in thermoelectric power sources for space probes and power supplies for cardiac devices is the potential for human exposure to 238Pu, primarily by inhalation. In the event of human internal exposure, a means is needed for assessing the level of intake and calculating radiation doses. Several bioassay/dosimetry models have been developed for 239Pu. However, results from studies with laboratory animals have indicated that the biokinetics, and therefore the descriptive models, of 238Pu are significantly different from those for 239Pu. A canine model accounting for these differences has been applied in this work to urinary excretion data from seven humans occupationally exposed to low levels of an insoluble 238Pu compound. The modified model provides a good description of the urinary excretion kinetics observed in the exposed humans. The modified model was also used to provide estimates of the initial intakes of 238Pu for the seven individuals; these estimates ranged from 4.5 nCi (170 Bq) to 87 nCi (3200 Bq). Autopsy data on the amount and distribution of 238Pu retained in the organs may be used in the future to validate or refute both these estimates and the assumptions used to formulate the human model. Modification of the human model to simulate an injection exposure to 239Pu gave patterns of retention in the organs and urinary excretion comparable to those seen previously in humans; further modification of the model using fecal data (unavailable for the subjects of this study) is indicated.},
doi = {10.2172/10189498},
url = {https://www.osti.gov/biblio/10189498}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1991},
month = {8}
}

Thesis/Dissertation:
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