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Development of a New Chelation Model: Bioassay Data Interpretation and Dose Assessment after Plutonium Intake via Wound and Treatment with DTPA

Journal Article · · Health Physics
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  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
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The administration of chelation therapy to treat significant intakes of actinides, such as plutonium, affects the actinide’s normal biokinetics. In particular, it enhances the actinide’s rate of excretion, such that the standard biokinetic models cannot be applied directly to the chelation-affected bioassay data in order to estimate the intake and assess the radiation dose. Here we propose a new chelation model that can be applied to the chelation-affected bioassay data after plutonium intake via wound and treatment with DTPA. In the proposed model, chelation is assumed to occur in the blood, liver, and parts of the skeleton. Ten datasets, consisting of measurements of 14C-DTPA, 238Pu, and 239Pu involving humans given radiolabeled DTPA and humans occupationally exposed to plutonium via wound and treated with chelation therapy, were used for model development. The combined dataset consisted of daily and cumulative excretion (urine and feces), wound counts, measurements of excised tissue, blood, and post-mortem tissue analyses of liver and skeleton. The combined data were simultaneously fit using the chelation model linked with a plutonium systemic model, which was linked to an ad hoc wound model. The proposed chelation model was used for dose assessment of the wound cases used in this study.
Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
89233218CNA000001
OSTI ID:
1739974
Report Number(s):
LA-UR--19-28424
Journal Information:
Health Physics, Journal Name: Health Physics Journal Issue: 6 Vol. 119; ISSN 0017-9078
Publisher:
Health Physics SocietyCopyright Statement
Country of Publication:
United States
Language:
English

References (29)

Validation of a system of models for plutonium decorporation therapy journal January 2019
Pulmonary retention of actinides after dissolution of PuO 2 aerosols: interest in modelling DTPA decorporation journal April 2008
An analysis of a puncture wound case with medical intervention journal July 2003
Distribution of Plutonium and Americium in Whole Bodies Donated to the United States Transuranium Registry journal January 1989
Modelling of bioassay data from a Pu wound treated by repeated DTPA perfusions: biokinetics and dosimetric approaches journal June 2007
Ustur whole body case 0269: demonstrating effectiveness of i.v. CA-DTPA for PU journal June 2007
AIDE: internal dosimetry software journal February 2008
Biokinetic modelling of DTPA decorporation therapy: the CONRAD approach journal February 2009
MADOR: a new tool to calculate decrease of effective doses in human after DTPA therapy journal December 2010
A Brief Overview of Compartmental Modeling for Intake of Plutonium via Wounds journal June 2017
Ustur Whole-Body case 0212: 17-Year Follow-Up of Plutonium Contaminated Wound journal July 2017
Interpretation of Human Urinary Excretion of Plutonium for Cases Treated with DTPA journal January 1972
Assessment and Management of a Plutonium Contaminated Wound Case journal January 1974
A Mathematical Model for Estimation of Plutonium in the Human Body from Urine Data Influenced by DTPA Therapy journal January 1978
The Retention of 14C-DTPA in Human Volunteers After Inhalation Or Intravenous Injection journal January 1983
Development of the Plutonium-DTPA Biokinetic Model journal January 2015
Plutonium-DTPA Model Application with USTUR Case 0269 journal January 2016
Interpretation of Urinary Excretion Data From Plutonium Wound Cases Treated With DTPA: Application of Different Models and Approaches journal January 2017
Application of NCRP 156 Wound Models for the Analysis of Bioassay Data from Plutonium Wound Cases journal January 2017
Some Considerations for Chelation Treatment and Surgical Excision Following Incorporation of Plutonium in Wounds journal January 2018
USTUR Case 0846: Modeling Americium Biokinetics After Intensive Decorporation Therapy journal November 2018
Bayesian Analysis of Plutonium Bioassay Data at Los Alamos National Laboratory journal January 2018
The Conrad Approach to Biokinetic Modeling of dtpa Decorporation Therapy journal January 2010
Structure of a Single Model to Describe Plutonium and Americium Decorporation by dtpa Treatments journal January 2010
Software for Empirical Building of Biokinetic Models for Normal and Decorporation-affected Data journal January 2012
In Vitro and In Vivo Assessment of Plutonium Speciation and Decorporation in Blood and Target Retention Tissues after a Systemic Contamination followed by an Early Treatment with DTPA journal August 2008
Americium Systemic Biokinetic Model for Rats journal May 2019
Simplified Structure of a New Model to Describe Urinary Excretion of Plutonium after Systemic, Liver or Pulmonary Contamination of Rats Associated with Ca-DTPA Treatments journal June 2009
Mayak Worker Study: An Improved Biokinetic Model for Reconstructing Doses from Internally Deposited Plutonium journal August 2005

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Related Subjects

60 APPLIED LIFE SCIENCES
DTPA
chelation
chelation modeling
dosimetry
internal
humans
internal dose
plutonium decorporation
radiation protection
wound