MIRD Pamphlet No. 21: A Generalized Schema for Radiopharmaceutical Dosimetry-Standardization of Nomenclature

Journal Article · Sun Mar 01 04:00:00 EST 2009 · Journal of Nuclear Medicine

DOI:https://doi.org/10.2967/jnumed.108.056036· OSTI ID:1015096

Bolch, W E ^[1]; Eckerman, Keith F ^[2]; Sgouros, George ^[3]; Thomas, Steven R ^[4]

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1. University of Florida, Gainesville
2. ORNL
3. Johns Hopkins University
4. University of Cincinnati

The internal dosimetry schema of the Medical Internal Radiation Dose (MIRD) Committee of the Society of Nuclear Medicine has provided a broad framework for assessment of the absorbed dose to whole organs, tissue subregions, voxelized tissue structures, and individual cellular compartments for use in both diagnostic and therapeutic nuclear medicine. The schema was originally published in 1968, revised in 1976, and republished in didactic form with comprehensive examples as the MIRD primer in 1988 and 1991. The International Commission on Radiological Protection (ICRP) is an organization that also supplies dosimetric models and technical data, for use in providing recommendations for limits on ionizing radiation exposure to workers and members of the general public. The ICRP has developed a dosimetry schema similar to that of the MIRD Committee but has used different terminology and symbols for fundamental quantities such as the absorbed fraction, specific absorbed fraction, and various dose coefficients. The MIRD Committee objectives for this pamphlet are 3-fold: to restate its schema for assessment of absorbed dose in a manner consistent with the needs of both the nuclear medicine and the radiation protection communities, with the goal of standardizing nomenclature; to formally adopt the dosimetry quantities equivalent dose and effective dose for use in comparative evaluations of potential risks of radiation-induced stochastic effects to patients after nuclear medicine procedures; and to discuss the need to identify dosimetry quantities based on absorbed dose that address deterministic effects relevant to targeted radionuclide therapy.

• Research Organization: Oak Ridge National Laboratory (ORNL); Oak Ridge National Environmental Research Park
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-00OR22725
• OSTI ID: 1015096
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: 3 Vol. 50; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
COMMUNITIES
COMPARATIVE EVALUATIONS
COMPARTMENTS
DOSIMETRY
ICRP schema
IONIZING RADIATIONS
MIRD schema
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION DOSES
RADIATION PROTECTION
RADIOISOTOPES
RADIOPHARMACEUTICALS
RECOMMENDATIONS
THERAPY
absorbed dose
effective dose
equivalent dose