Determination of radiobiological parameters for the safe clinical application of BNCT

Technical Report · Fri Dec 31 04:00:00 EST 1993

DOI:https://doi.org/10.2172/10136300· OSTI ID:10136300

Hopewell, J W; Morris, G M ^[1]; Coderre, J A ^[2]

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1. Univ. of Oxford (United Kingdom). Research Inst.
2. Brookhaven National Lab., Upton, NY (United States)

In the present report the effects of BNCT irradiation on the skin and spinal cord of Fischer 344 rats, for known concentrations of {sup 10}B in the blood and these normal tissues, are compared with the effects of the neutron beam alone or photon irradiation. The biological effectiveness of irradiation in the presence of the capture agents BSH and BPA have been compared. Irradiations were carried out using the thermal beam of the Brookhaven Medical Research Reactor (BMRR). Therapy experiments were also carried out as part of this study, using the rat 9L-gliosarcoma cell line, in order to establish the potential therapeutic advantage that might be achieved using the above capture agents. This cell line grows as a solid tumor in vivo as well as in vitro. The implications of these findings, with respect to the clinical use of the Petten HBII based epithermal neutron beam, will be discussed.

• Research Organization: Brookhaven National Lab., Upton, NY (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 10136300
• Report Number(s): BNL--60066; CONF-9309357--; ON: DE94008995
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
BORON 10
EVALUATION
EXPERIMENTAL DATA
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RADIOTHERAPY
RBE
SARCOMAS
UNSEALED RADIONUCLIDES IN THERAPY