Boron neutron capture irradiation of the rat spinal cord: Histopathological evidence of a vascular-mediated pathogenesis
- Univ. of Oxford, Oxford (United Kingdom)
- Brookhaven National Lab., Upton, NY (United States)
A histopathological study was carried out on the spinal cord of rats after boron neutron capture (BNC) irradiation. Rats were irradiated with thermal neutrons alone or in combination with borocaptate sodium (BSH) or p-boronophenylalanine (BPA). Spinal cords were examined 1 year after irradiation, or at earlier times in rats developing myelothapy. Considered overall, the pathology of the spinal cord after BNC irradiation was comparable with that reported previously after X irradiation of the spinal cord in the identical strain of rat. When BSH was used as the neutron capture agent, the biologically effective dose of radiation delivered to the CNS parechyma was a factor of {approx}2.7 lower than that delivered to the vascular endothelium. In effect, the blood vessels were selectively irradiated using this BNC modality. The resultant pathology was similar to that observed after irradiation with thermal neutrons alone or in the presence of BPA, situations in which the CNS vasculature was not selectively irradiated. This points to the vascular endothelium as being the critical target cell population, damage to which results in the development of the lesions seen in the spinal cord after BNC irradiation and, by inference, after irradiation with more conventional modalities. 37 refs., 6 figs., 4 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 381110
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 3 Vol. 146; ISSN 0033-7587; ISSN RAREAE
- Country of Publication:
- United States
- Language:
- English
Similar Records
Boron neutron capture therapy: A guide to the understanding of the pathogenesis of late radiation damage to the rat spinal cord
Comparative assessment of single-dose and fractionated boron neutron capture therapy
Effect of x rays and neutrons on repair and regeneration in the rat spinal cord
Journal Article
·
Tue Mar 29 23:00:00 EST 1994
· International Journal of Radiation Oncology, Biology and Physics; (United States)
·
OSTI ID:6900486
Comparative assessment of single-dose and fractionated boron neutron capture therapy
Journal Article
·
Thu Nov 30 23:00:00 EST 1995
· Radiation Research
·
OSTI ID:186114
Effect of x rays and neutrons on repair and regeneration in the rat spinal cord
Journal Article
·
Tue Nov 30 23:00:00 EST 1982
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5145594