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Title: A linear, time-varying simulation of the respiratory tract system

Abstract

These results show that regional deposition efficiencies of inhaled particles are highly dependent on the level of physical activity in all the spectrum of thermodynamic and aerodynamic aerosol particle sizes; also it was shown that for particles in the aerodynamic size range, the values of regional deposition efficiencies at the inner regions of the lung are highly dependent on age. In addition, the shape of regional deposition efficiency curves as a function of particle size have a similar behavior for all ages; thus, any variation of the airway geometry and respiratory physiological parameters such as tidal volumes and breathing frequencies due to age difference do not cause a change in the fundamental mechanisms of deposition. Thus, for all the cases of physical activity and age dependency, the deposition of ultrafine aerosol particles is highly enhanced by diffusive processes in all regions of the respiratory tract, and for very large aerosol size particles this behavior is repeated again due to impaction and sedimentation mechanisms. Although the results presented at this work, are the result of computer simulations based on different sources of experimental data, the structure of the computer simulation code BIODEP is flexible enough to the acquisition of any kindmore » of new experimental information in terms of biokinetic analysis and regional deposition parameters. In addition, since the design of BIODEP was intended for easy access to the users, then with exception of the subroutine DIVPAG, at this moment, the modular design of BIODEP using FORTRAN 77 allows the implementation of all the subroutines of BIODEP to be used in a interactive mode with any microcomputer.« less

Authors:
 [1]
  1. Texas A & M Univ., College Station, TX (United States)
Publication Date:
Research Org.:
Texas A & M Univ., College Station, TX (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
10110476
Report Number(s):
DOE/ER/60707-T3
ON: DE93004515
DOE Contract Number:  
FG05-88ER60707
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: TH: Thesis (Ph.D.); PBD: Nov 1992
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RESPIRATORY SYSTEM; MATHEMATICAL MODELS; LUNG CLEARANCE; RADIONUCLIDE KINETICS; TRANSURANIUM ELEMENTS; INHALATION; RADIATION DOSES; RADIATION PROTECTION; RADIOACTIVE AEROSOLS; BODY BURDEN; BIOLOGICAL LOCALIZATION; MATRICES; EXERCISE; 560101; 560161; DOSIMETRY AND MONITORING; MAN

Citation Formats

Hernandez, Oscar. A linear, time-varying simulation of the respiratory tract system. United States: N. p., 1992. Web. doi:10.2172/10110476.
Hernandez, Oscar. A linear, time-varying simulation of the respiratory tract system. United States. https://doi.org/10.2172/10110476
Hernandez, Oscar. Sun . "A linear, time-varying simulation of the respiratory tract system". United States. https://doi.org/10.2172/10110476. https://www.osti.gov/servlets/purl/10110476.
@article{osti_10110476,
title = {A linear, time-varying simulation of the respiratory tract system},
author = {Hernandez, Oscar},
abstractNote = {These results show that regional deposition efficiencies of inhaled particles are highly dependent on the level of physical activity in all the spectrum of thermodynamic and aerodynamic aerosol particle sizes; also it was shown that for particles in the aerodynamic size range, the values of regional deposition efficiencies at the inner regions of the lung are highly dependent on age. In addition, the shape of regional deposition efficiency curves as a function of particle size have a similar behavior for all ages; thus, any variation of the airway geometry and respiratory physiological parameters such as tidal volumes and breathing frequencies due to age difference do not cause a change in the fundamental mechanisms of deposition. Thus, for all the cases of physical activity and age dependency, the deposition of ultrafine aerosol particles is highly enhanced by diffusive processes in all regions of the respiratory tract, and for very large aerosol size particles this behavior is repeated again due to impaction and sedimentation mechanisms. Although the results presented at this work, are the result of computer simulations based on different sources of experimental data, the structure of the computer simulation code BIODEP is flexible enough to the acquisition of any kind of new experimental information in terms of biokinetic analysis and regional deposition parameters. In addition, since the design of BIODEP was intended for easy access to the users, then with exception of the subroutine DIVPAG, at this moment, the modular design of BIODEP using FORTRAN 77 allows the implementation of all the subroutines of BIODEP to be used in a interactive mode with any microcomputer.},
doi = {10.2172/10110476},
url = {https://www.osti.gov/biblio/10110476}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1992},
month = {11}
}

Thesis/Dissertation:
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