A linear, time-varying simulation of the respiratory tract system
- Texas A & M Univ., College Station, TX (United States)
These results show that regional deposition efficiencies of inhaled particles are highly dependent on the level of physical activity in all the spectrum of thermodynamic and aerodynamic aerosol particle sizes; also it was shown that for particles in the aerodynamic size range, the values of regional deposition efficiencies at the inner regions of the lung are highly dependent on age. In addition, the shape of regional deposition efficiency curves as a function of particle size have a similar behavior for all ages; thus, any variation of the airway geometry and respiratory physiological parameters such as tidal volumes and breathing frequencies due to age difference do not cause a change in the fundamental mechanisms of deposition. Thus, for all the cases of physical activity and age dependency, the deposition of ultrafine aerosol particles is highly enhanced by diffusive processes in all regions of the respiratory tract, and for very large aerosol size particles this behavior is repeated again due to impaction and sedimentation mechanisms. Although the results presented at this work, are the result of computer simulations based on different sources of experimental data, the structure of the computer simulation code BIODEP is flexible enough to the acquisition of any kind of new experimental information in terms of biokinetic analysis and regional deposition parameters. In addition, since the design of BIODEP was intended for easy access to the users, then with exception of the subroutine DIVPAG, at this moment, the modular design of BIODEP using FORTRAN 77 allows the implementation of all the subroutines of BIODEP to be used in a interactive mode with any microcomputer.
- Research Organization:
- Texas A & M Univ., College Station, TX (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG05-88ER60707
- OSTI ID:
- 10110476
- Report Number(s):
- DOE/ER/60707-T3; ON: DE93004515
- Resource Relation:
- Other Information: TH: Thesis (Ph.D.); PBD: Nov 1992
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RESPIRATORY SYSTEM
MATHEMATICAL MODELS
LUNG CLEARANCE
RADIONUCLIDE KINETICS
TRANSURANIUM ELEMENTS
INHALATION
RADIATION DOSES
RADIATION PROTECTION
RADIOACTIVE AEROSOLS
BODY BURDEN
BIOLOGICAL LOCALIZATION
MATRICES
EXERCISE
560101
560161
DOSIMETRY AND MONITORING
MAN