Mutagenicity of radon and radon daughters. Annual progress report
The objective of our research is to investigate the dose-response relationship of the lethal and mutagenic effects of exposure of cells to radon and its decay products. Dose rate dependence and the nature of the DNA lesion will be studied, using the thymidine kinase and HPRT loci to measure mutation frequency. A deficiency in DNA repair is shown to lead to a greater proportion of mutants with intergenic lesions. The cytotoxic effects of radon and its daughters are similar in human TK6 lymphoblasts and mouse L5178Y lymphoblasts, the cell line used in previous experiments. The results of molecular analysis of four spontaneous and 25 X-radiation induced HPRT{sup {minus}} mutants. Eleven radon-induced HPRT{sup {minus}} mutants have been isolated, and will be analyzed in a similar fashion. 9 figs.
- Research Organization:
- Case Western Reserve Univ., Cleveland, OH (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-88ER60658
- OSTI ID:
- 10103411
- Report Number(s):
- DOE/ER/60658--4; ON: DE92003695
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
DAUGHTER PRODUCTS
DESIGN
DOSE RATES
DOSIMETRY
GENE MUTATIONS
MAN
MICE
PROGRESS REPORT
RADIATION DOSES
RADIOINDUCTION
RADIOISOTOPE GENERATORS
RADIONUCLIDE EFFECTS, KINETICS, AND TOXICOLOGY
RADON
X RADIATION