Detection, identification and mapping of iron anomalies in brain tissue using X-ray absorption spectroscopy

Journal Article · Mon Jun 16 04:00:00 EDT 2008 · J. Roy. Soc. Inter.

OSTI ID:1008622

Mikhaylova, A; Davidson, M; Toastmann, H; Channell, J E.T.; Guyodo, Y; Batich, C; Dobson, J ^[1]

---

1. Keele

This work describes a novel method for the detection, identification and mapping of anomalous iron compounds in mammalian brain tissue using X-ray absorption spectroscopy. We have located and identified individual iron anomalies in an avian tissue model associated with ferritin, biogenic magnetite and haemoglobin with a pixel resolution of less than 5 {micro}m. This technique represents a breakthrough in the study of both intra- and extra-cellular iron compounds in brain tissue. The potential for high-resolution iron mapping using microfocused X-ray beams has direct application to investigations of the location and structural form of iron compounds associated with human neurodegenerative disorders - a problem which has vexed researchers for 50 years.

• Research Organization: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
• Sponsoring Organization: USDOE
• OSTI ID: 1008622
• Journal Information: J. Roy. Soc. Inter., Journal Name: J. Roy. Soc. Inter. Journal Issue: (2) ; 03, 2005 Vol. 2; ISSN 1742-5662
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

60 APPLIED LIFE SCIENCES
ABSORPTION SPECTROSCOPY
ANIMAL TISSUES
BRAIN
DETECTION
FERRITIN
HEMOGLOBIN
IRON COMPOUNDS
MAGNETITE
NERVOUS SYSTEM DISEASES
X-RAY SPECTROSCOPY