Mapping and characterization of iron compounds in Alzheimer's tissue
Journal Article
·
· J. Alzheimers Dis.
OSTI ID:1007722
- Keele
Understanding the management of iron in the brain is of great importance in the study of neurodegeneration, where regional iron overload is frequently evident. A variety of approaches have been employed, from quantifying iron in various anatomical structures, to identifying genetic risk factors related to iron metabolism, and exploring chelation approaches to tackle iron overload in neurodegenerative disease. However, the ease with which iron can change valence state ensures that it is present in vivo in a wide variety of forms, both soluble and insoluble. Here, we review recent developments in approaches to locate and identify iron compounds in neurodegenerative tissue. In addition to complementary techniques that allow us to quantify and identify iron compounds using magnetometry, extraction, and electron microscopy, we are utilizing a powerful combined mapping/characterization approach with synchrotron X-rays. This has enabled the location and characterization of iron accumulations containing magnetite and ferritin in human Alzheimer's disease (AD) brain tissue sections in situ at micron-resolution. It is hoped that such approaches will contribute to our understanding of the role of unusual iron accumulations in disease pathogenesis, and optimise the potential to use brain iron as a clinical biomarker for early detection and diagnosis.
- Research Organization:
- Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1007722
- Journal Information:
- J. Alzheimers Dis., Journal Name: J. Alzheimers Dis. Journal Issue: (2-3) ; 11, 2006 Vol. 10
- Country of Publication:
- United States
- Language:
- ENGLISH
Similar Records
In-situ Characterization and Mapping of Iron Compounds in Alzheimer's Tissue
High-resolution x-ray absorption spectroscopy studies of metal compounds in neurodegenerative brain tissue
Detection, identification and mapping of iron anomalies in brain tissue using X-ray absorption spectroscopy
Journal Article
·
Mon Jun 16 00:00:00 EDT 2008
· J. Alzheimers Dis.
·
OSTI ID:1008629
High-resolution x-ray absorption spectroscopy studies of metal compounds in neurodegenerative brain tissue
Conference
·
Mon Jun 16 00:00:00 EDT 2008
·
OSTI ID:1008958
Detection, identification and mapping of iron anomalies in brain tissue using X-ray absorption spectroscopy
Journal Article
·
Mon Jun 16 00:00:00 EDT 2008
· J. Roy. Soc. Inter.
·
OSTI ID:1008622