Method for protection against genotoxic mutagenesis

Grdina, David J

Title: Method for protection against genotoxic mutagenesis

Patent · Mon Jan 01 00:00:00 EST 1996

OSTI ID:870650

Grdina, David J ^[1]

Naperville, IL

A method and pharmaceutical for protecting against mutational damage in mammalian cells, irrespective of the nature of the mutagenic event or source of radiational or chemical insult or the like.

View Patent

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

DOE Contract Number:: W-31109-ENG-38

Assignee:: Arch Development Corporation (Chicago, IL)

Patent Number(s):: US 5567686

OSTI ID:: 870650

Country of Publication:: United States

Language:: English

References (26)

Inhibition of topoisomerase II activity in repair-proficient CHO K1 cells by 2-[(aminopropyl)amino]ethanethiol (WR-1065) Grdina, D. J.; Constantinou, A.; Shigematsu, N. https://doi.org/10.2172/10184593	report	September 1992
The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells Grdina, David J.; Nagy, Biserka; Hill, Colin K. Carcinogenesis, Vol. 6, Issue 6 https://doi.org/10.1093/carcin/6.6.929	journal	January 1985
Mitochondrial DNA alterations as ageing-associated molecular events Wei, Yau-Huei Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90019-L	journal	September 1992
Oxidative and other DNA damages as the basis of aging: a review Holmes, George E.; Bernstein, Carol; Bernstein, Harris Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90034-M	journal	September 1992
Endogenous glutathione levels modulate the frequency of both spontaneous and long wavelength ultraviolet induced mutations in human cells Applegate, L. A.; Lautier, D.; Frenk, E. Carcinogenesis, Vol. 13, Issue 9 https://doi.org/10.1093/carcin/13.9.1557	journal	January 1992
Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR1065 Zhang, Xiafang; Lai, Peter; Taylor, Ybonne International Journal of Radiation OncologyBiologyPhysics, Vol. 21 https://doi.org/10.1016/0360-3016(91)90458-G	journal	January 1991
Protection against Radiation-Induced Mutagenesis in V79 Cells by 2-[(Aminopropyl)amino] Ethanethiol under Conditions of Acute Hypoxia Grdina, David J.; Nagy, Biserka; Hill, Colin K. Radiation Research, Vol. 117, Issue 2 https://doi.org/10.2307/3577326	journal	February 1989
Differential Effects of Radical Scavengers on X-Ray-Induced Mutation and Cytotoxicity in Human Cells Corn, Benjamin W.; Liber, Howard L.; Little, John B. Radiation Research, Vol. 109, Issue 1 https://doi.org/10.2307/3576871	journal	January 1987
Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326 Grdina, D. J.; Dale, P.; Weichselbaum, R. International Journal of Radiation OncologyBiologyPhysics, Vol. 22, Issue 4 https://doi.org/10.1016/0360-3016(92)90530-U	journal	January 1992
Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278 Holwitt, Eric A.; Koda, Erik; Swenberg, C. E. Radiation Research, Vol. 124, Issue 1 https://doi.org/10.2307/3577703	journal	October 1990
The inhibitory effect of cysteine on the mutagenic activities of several carcinogens Rosin, Miriam P.; Stich, H. F. Mutation Research/Environmental Mutagenesis and Related Subjects, Vol. 54, Issue 1 https://doi.org/10.1016/0165-1161(78)90137-1	journal	August 1978
The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation Grdina, David J.; Kataoka, Yasushi; Basic, Ivan Carcinogenesis, Vol. 13, Issue 5 https://doi.org/10.1093/carcin/13.5.811	journal	January 1992
Preface: Aging of the 25th chromosome Joenje, Hans Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90015-H	journal	September 1992
Chemical Protection against the Long-Term Effects of a Single Whole-Body Exposure of Mice to Ionizing Radiation: I. Life Shortening Maisin, J. R.; Mattelin, G.; Lambiet-Collier, M. Radiation Research, Vol. 71, Issue 1 https://doi.org/10.2307/3574717	journal	July 1977
Models for thiol protection of DNA in cells Held, Kathryn D. Pharmacology & Therapeutics, Vol. 39, Issue 1-3 https://doi.org/10.1016/0163-7258(88)90050-2	journal	January 1988
Protection by WR-2721 of human bone marrow function following irradiation Constine, Louis S.; Zagars, Gunar; Rubin, Philip International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 8 https://doi.org/10.1016/0360-3016(86)90204-X	journal	August 1986
Protection by WR-151327 against Late-Effect Damage from Fission-Spectrum Neutrons Grdina, D. J.; Wright, B. J.; Carnes, B. A. Radiation Research, Vol. 128, Issue 1 https://doi.org/10.2307/3578014	journal	October 1991
Antimutagenic Effects of Radioprotector WR-2721 Against Fission-spectrum Neutrons and ⁶⁰ Co γ-rays in Mice Kataoka, Y.; Basic, I.; Perrin, J. International Journal of Radiation Biology, Vol. 61, Issue 3 https://doi.org/10.1080/09553009214551081	journal	January 1992
In Vivo Protection by the Aminothiol WR-2721 against Neutron-induced Carcinogenesis Carnes, B. A.; Grdina, D. J. International Journal of Radiation Biology, Vol. 61, Issue 5 https://doi.org/10.1080/09553009214551381	journal	January 1992
Pathological Effects of the Radiation Protector WR-151327 in Mice van Beek, M. E. A. B.; Doak, R. L.; Sigdestad, C. P. Radiation Research, Vol. 124, Issue 1 https://doi.org/10.2307/3577698	journal	October 1990
DNA, mutations and aging Kirkwood, T. B. L. Mutation Research/DNAging, Vol. 219, Issue 1 https://doi.org/10.1016/0921-8734(89)90035-0	journal	January 1989
Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention Linnane, Anthony W.; Zhang, Chunfang; Baumer, Alessandra Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90023-I	journal	September 1992
Antimutagenic properties of WR 2721 and of a radioprotective mixture, ATP-AET-serotonin, with regard to X ray induced reciprocal translocations in mouse spermatogonia Benova, D. International Journal of Radiation OncologyBiologyPhysics, Vol. 13, Issue 1 https://doi.org/10.1016/0360-3016(87)90268-9	journal	January 1987
Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells Nagy, B.; Grdina, D. J. International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 8 https://doi.org/10.1016/0360-3016(86)90197-5	journal	August 1986
Radiation Protectors: the Unexpected Benefits Grdina, David J.; Sigdestad, Curtis P. Drug Metabolism Reviews, Vol. 20, Issue 1 https://doi.org/10.3109/03602538908994143	journal	January 1989
Natural antioxidants as inhibitors of oxygen species induced mutagenicity Minnunni, M.; Wolleb, U.; Mueller, O. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 269, Issue 2 https://doi.org/10.1016/0027-5107(92)90200-L	journal	October 1992

Similar Records

Method for protection against genotoxic mutagenesis

Patent · Tue Feb 09 00:00:00 EST 1999 · OSTI ID:870650

Grdina, David J

Method for protection against genotoxic mutagenesis

Patent · Tue Jan 30 00:00:00 EST 1996 · OSTI ID:870650

Grdina, D J

Method for protection against genotoxic mutagenesis

Patent · Mon Jan 01 00:00:00 EST 1996 · OSTI ID:870650

Grdina, David J

Related Subjects

method
protection
genotoxic
mutagenesis
pharmaceutical
protecting
mutational
damage
mammalian
cells
irrespective
nature
mutagenic
event
source
radiational
chemical
insult
mammalian cells
chemical insult
mutational damage
mutagenic event
genotoxic mutagenesis
/514/

Title: Method for protection against genotoxic mutagenesis

Citation Formats

References (26)

Similar Records

Related Subjects