Method for protection against genotoxic mutagenesis
Patent
·
OSTI ID:187071
A method and pharmaceutical for protecting against genotoxic damage in irradiated cells are disclosed. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides. 10 figs.
- Research Organization:
- Univ. of Chicago, IL (United States)
- DOE Contract Number:
- W-31109-ENG-38
- Assignee:
- Arch Development Corp., Chicago, IL (United States)
- Patent Number(s):
- US 5,488,042/A/
- Application Number:
- PAN: 7-851,210; TRN: 96:006434
- OSTI ID:
- 187071
- Resource Relation:
- Other Information: PBD: 30 Jan 1996
- Country of Publication:
- United States
- Language:
- English
Similar Records
Method for protection against genotoxic mutagenesis
WR-2721 protects against cytoxan-induced hprt mutagenesis without affecting therapeutic effectiveness
Protection against radiation-induced mutations at the hprt locus by spermine and N,N{double_prime}-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278). WR-33278 and spermine protect against mutation induction
Patent
·
Mon Jan 01 00:00:00 EST 1996
·
OSTI ID:187071
WR-2721 protects against cytoxan-induced hprt mutagenesis without affecting therapeutic effectiveness
Conference
·
Sun Dec 31 00:00:00 EST 1995
·
OSTI ID:187071
+2 more
Protection against radiation-induced mutations at the hprt locus by spermine and N,N{double_prime}-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278). WR-33278 and spermine protect against mutation induction
Technical Report
·
Mon Aug 01 00:00:00 EDT 1994
·
OSTI ID:187071