Method for protection against genotoxic mutagenesis

Grdina, David J

Title: Method for protection against genotoxic mutagenesis

Patent · Mon Jan 01 00:00:00 EST 1996

OSTI ID:870278

Grdina, David J ^[1]

Naperville, IL

A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

DOE Contract Number:: W-31109-ENG-38

Assignee:: Arch Development Corporation (Chicago, IL)

Patent Number(s):: US 5488042

OSTI ID:: 870278

Country of Publication:: United States

Language:: English

References (15)

Models for thiol protection of DNA in cells Held, Kathryn D. Pharmacology & Therapeutics, Vol. 39, Issue 1-3 https://doi.org/10.1016/0163-7258(88)90050-2	journal	January 1988
Protection by WR-2721 of human bone marrow function following irradiation Constine, Louis S.; Zagars, Gunar; Rubin, Philip International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 8 https://doi.org/10.1016/0360-3016(86)90204-X	journal	August 1986
Protection by WR-151327 against Late-Effect Damage from Fission-Spectrum Neutrons Grdina, D. J.; Wright, B. J.; Carnes, B. A. Radiation Research, Vol. 128, Issue 1 https://doi.org/10.2307/3578014	journal	October 1991
Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR1065 Zhang, Xiafang; Lai, Peter; Taylor, Ybonne International Journal of Radiation OncologyBiologyPhysics, Vol. 21 https://doi.org/10.1016/0360-3016(91)90458-G	journal	January 1991
Protection against Radiation-Induced Mutagenesis in V79 Cells by 2-[(Aminopropyl)amino] Ethanethiol under Conditions of Acute Hypoxia Grdina, David J.; Nagy, Biserka; Hill, Colin K. Radiation Research, Vol. 117, Issue 2 https://doi.org/10.2307/3577326	journal	February 1989
Antimutagenic Effects of Radioprotector WR-2721 Against Fission-spectrum Neutrons and ⁶⁰ Co γ-rays in Mice Kataoka, Y.; Basic, I.; Perrin, J. International Journal of Radiation Biology, Vol. 61, Issue 3 https://doi.org/10.1080/09553009214551081	journal	January 1992
Differential Effects of Radical Scavengers on X-Ray-Induced Mutation and Cytotoxicity in Human Cells Corn, Benjamin W.; Liber, Howard L.; Little, John B. Radiation Research, Vol. 109, Issue 1 https://doi.org/10.2307/3576871	journal	January 1987
Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326 Grdina, D. J.; Dale, P.; Weichselbaum, R. International Journal of Radiation OncologyBiologyPhysics, Vol. 22, Issue 4 https://doi.org/10.1016/0360-3016(92)90530-U	journal	January 1992
In Vivo Protection by the Aminothiol WR-2721 against Neutron-induced Carcinogenesis Carnes, B. A.; Grdina, D. J. International Journal of Radiation Biology, Vol. 61, Issue 5 https://doi.org/10.1080/09553009214551381	journal	January 1992
Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278 Holwitt, Eric A.; Koda, Erik; Swenberg, C. E. Radiation Research, Vol. 124, Issue 1 https://doi.org/10.2307/3577703	journal	October 1990
The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation Grdina, David J.; Kataoka, Yasushi; Basic, Ivan Carcinogenesis, Vol. 13, Issue 5 https://doi.org/10.1093/carcin/13.5.811	journal	January 1992
Antimutagenic properties of WR 2721 and of a radioprotective mixture, ATP-AET-serotonin, with regard to X ray induced reciprocal translocations in mouse spermatogonia Benova, D. International Journal of Radiation OncologyBiologyPhysics, Vol. 13, Issue 1 https://doi.org/10.1016/0360-3016(87)90268-9	journal	January 1987
Radiation Protectors: the Unexpected Benefits Grdina, David J.; Sigdestad, Curtis P. Drug Metabolism Reviews, Vol. 20, Issue 1 https://doi.org/10.3109/03602538908994143	journal	January 1989
Binding of aminoalkylphosphorothioate radioprotective drugs to rodent tissue proteins Livesey, John C.; Grunbaum, Zdenka; Krohn, Kenneth A. Biochemical Pharmacology, Vol. 39, Issue 11 https://doi.org/10.1016/0006-2952(90)90129-9	journal	June 1990
Chemical Protection against the Long-Term Effects of a Single Whole-Body Exposure of Mice to Ionizing Radiation: I. Life Shortening Maisin, J. R.; Mattelin, G.; Lambiet-Collier, M. Radiation Research, Vol. 71, Issue 1 https://doi.org/10.2307/3574717	journal	July 1977

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Related Subjects

method
protection
genotoxic
mutagenesis
pharmaceutical
protecting
damage
irradiated
cells
reduction
mutations
hypoxanthine-guanine
phosphoribosyl
transferase
locus
accomplished
administering
effective
dose
compound
protected
sulfhydryl
metabolize
vivo
produce
free
disulfides
genotoxic mutagenesis
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Title: Method for protection against genotoxic mutagenesis

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References (15)

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