Tellurium-123m-labeled isosteres of palmitoleic and oleic acids show high myocardial uptake
These studies were directed at determining if the telluro fatty acids prepared by the isosteric replacement of the ..delta../sup 9/-double bonds of oleic and palmitoleic acids with /sup 123m/Te would show heart uptake in rats. The isostere of palmitoleic acid, 9-tellurapentadecanoic acid(II), was prepared by basic hydrolysis of the product formed by the coupling of /sup 123m/Te-sodium hexyl tellurol with methyl-8-bromooctadecanoate. Similarly, the isostere of oleic acid, 9-telluraheptadecanoic acid(IV), was prepared by the same route beginning with the reaction of /sup 123m/Te-sodium octyl tellurol with methyl-8-bromooctadecanoate. Both /sup 123m/Te-(II) and /sup 123m/Te-(IV) showed remarkably high heart uptake in rats (2 to 3% dose/gm) ten minutes after intravenous administration, and the heart/blood ratios were high (20-30/1). Finally, the hearts of rats injected with /sup 123m/Te-(IV) have been clearly imaged with a rectilinear scanner.
- Research Organization:
- Oak Ridge National Lab., TN (USA); Texas A and M Univ., College Station (USA). Dept. of Chemistry
- Sponsoring Organization:
- USDOE Office of Environment, Safety and Health (EH)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6298922
- Report Number(s):
- CONF-790321-3; TRN: 79-010707
- Resource Relation:
- Conference: 2. international symposium on radiopharmaceuticals, Seattle, WA, USA, 18 Mar 1979
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MONOCARBOXYLIC ACIDS
LABELLING
RADIOPHARMACEUTICALS
MYOCARDIUM
SCINTISCANNING
BIOLOGICAL LOCALIZATION
CHEMICAL PREPARATION
TELLURIUM 123
RADIOCHEMISTRY
ISOMERIC NUCLEI
OLEIC ACID
RATS
ANIMALS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMISTRY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
EVEN-ODD NUCLEI
HEART
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
STABLE ISOTOPES
SYNTHESIS
TELLURIUM ISOTOPES
VERTEBRATES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
550601 - Medicine- Unsealed Radionuclides in Diagnostics
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)