Nuclear medicine technology progress report for quarter ending December 31, 1981. [YOCARDIUM; SCINTISCANNING; TELLURIUM COMPOUNDS; PHYSICAL PROPERTIES]
The synthesis and preliminary evaluation of a radioiodinated tellurium long-chain fatty acid in which the iodine is stabilized by attachment to the para-position of a terminal phenyl ring is described. Radioiodinated (/sup 125/I and /sup 131/I) 15-(p-iodophenyl)-6-tellurapentadecanoic acid was prepared by a rapid and high-yield triazene decomposition reaction involving treatment of a piperidyltriazene intermediate with radioiodide in the presence of acid. The radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid shows rapid, pronounced myocardial uptake in rats and also exhibits the prolonged retention observed earlier with 9-(/sup 123m/Te)telluraheptadecanoic acid (9-(/sup 123m/Te)THDA). Only minimal blood activity was detected and the heart:blood ratios were high. Also described is the synthesis of a series of trialkylphosphinegold-..beta..-thio-D-glucosetetraacetate analogs (R/sub 3/PAu-..beta..-D-TGTA). The new compounds are the trimethyl-(Me/sub 3/P-), triisopropyl-(i-Pr/sub 3/P-), tri-n-butyl-(n-Bu/sub 3/P-) and triphenyl-(phi/sub 3/P-) phosphine gold analogs. (ERB)
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5192170
- Report Number(s):
- ORNL/TM-8186; ON: DE82014654
- Resource Relation:
- Other Information: Portions of document are illegible
- Country of Publication:
- United States
- Language:
- English
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New, well-retained myocardial imaging agent: radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid
Nuclear medicine technology. Progress report for quarter ending September 30, 1981
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
CARBOXYLIC ACID ESTERS
RADIOPHARMACEUTICALS
IODINE 125
IODINE 131
CHEMICAL PREPARATION
ACETIC ACID ESTERS
GOLD COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
HEART
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYNTHESIS
TRANSITION ELEMENT COMPOUNDS
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
550601 - Medicine- Unsealed Radionuclides in Diagnostics
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)