A new, well-retained myocardial imaging agent: radioiodinated 15-(p-lodophenyl)-6-tellurapentadecanoic acid
A method involving the acid-catalyzed decomposition of a piperidyltriazene intermediate in the presence of radioiodide has been developed for the synthesis of radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid. The iodine-125-labeled agent shows rapid, pronounced myocardial uptake in rats (5.30-6.45% injected dose/g after 5 min) and also exhibits the prolonged retention previously observed with 9-(/sup 123m/Te)telluraheptadecanoic acid (9-/sup 123m/Te)HDA). After 6 hr, the heart uptake remained high (3.89-5.33%) dose/g) and decreased only to 3.02-3.41% dose/g after 24 hr. Very low blood activity was detected (0.24-0.27% dose/g at 5 min; 0.29-0.32% dose/g at 6 hr) and the heart-to-blood ratios were high (22:1 at 5 min; 15:1 at 6 hr). Minimal deiodination was demonstrated by the low thyroid uptake (1.41-1.63% dose/g at 5 min; 5.33-7.08% dose/g at 6 hr). The rapid and pronounced uptake, prolonged myocardial retention, and low in vivo deiodination make this agent attractive for further evaluation.
- Research Organization:
- Oak Ridge National Laboratory, Tennessee
- OSTI ID:
- 6584805
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:10
- Country of Publication:
- United States
- Language:
- English
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MYOCARDIUM
RADIOISOTOPE SCANNING
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
BLOOD
IODINE 125
ISOMERIC NUCLEI
RATS
RETENTION
TELLURIUM 123
THYROID
UPTAKE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
HEART
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
STABLE ISOTOPES
TELLURIUM ISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics