New, well-retained myocardial imaging agent: radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid
A method involving the acid-catalyzed decomposition of a piperidyltriazene intermediate in the presence of radioiodide has been developed for the synthesis of radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid. The iodine-125-labeled agent shows rapid, pronounced myocardial uptake in rats (5.30-6.45% injected dose/g after 5 min) and also exhibits the prolonged retention previously observed with 9-(/sup 123m/Te)telluraheptadecanoic acid (9-(/sup 123m/Te)HDA). After 6 hr, the heart uptake remained high (3.89-5.33% dose/g) and decreased only to 3.02-3.41% dose/g after 24 hr. Very low blood activity was detected (0.24-0.27% dose/g at 5 min; 0.29-0.32% dose/g at 6 hr) and the heart-to-blood ratios were high (22:1 at 5 min; 15:1 at 6 hr). Minimal deiodination was demonstrated by the low thyroid uptake (1.41-1.63% dose/g at 5 min; 5.33-7.08% dose/g at 6 hr). The rapid and pronounced uptake, prolonged myocardial retention, and low in vivo deiodination make this agent attractive for further evaluation.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 6862379
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:10
- Country of Publication:
- United States
- Language:
- English
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Nuclear medicine technology progress report for quarter ending December 31, 1981. [YOCARDIUM; SCINTISCANNING; TELLURIUM COMPOUNDS; PHYSICAL PROPERTIES]
New myocardial imaging agents: stabilization of radioiodine as a terminal vinyl iodide moiety on tellurium fatty acids
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IODINE 125
TISSUE DISTRIBUTION
UPTAKE
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
IODINATION
LABELLED COMPOUNDS
MONOCARBOXYLIC ACIDS
MYOCARDIUM
RATS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HALOGENATION
HEART
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
SYNTHESIS
VERTEBRATES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)