Biological availability of nickel arsenides: toxic effects of particulate Ni/sub 5/As/sub 2/
Considerations of (1) oil shale retort operating conditions, (2) oil shale elemental composition, (3) nickel and arsenic physico-chemical properties, and (4) oil shale matrix structure lead to the suggestion that nickel arsenides may be formed during the oil shale retorting process. The biological effects of nickel arsenides have not been previously studied. However, similarities between nickel subarsenide and nickel subsulfide and nickel subselenimide, both of which are known potent carcinogens, have caused concern that nickel arsenides may have adverse effects on biological systems. To determine if fugitive nickel arsenides from an oil shale retort could pose a threat to personnel in the workplace or to other living organisms in the environment, a program to study the toxicity of nickel arsenides has been initiated. Five stable nickel arsenides (Ni/sub 5/As/sub 2/, Ni/sub 2/As, Ni/sub 11/As/sub 8/, NiAs, and NiAs/sub 2/) and nickel arsenic sulfide (NiAsS) are considered possible species for study.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 6158404
- Report Number(s):
- LA-UR-81-2708; CONF-811035-1; ON: DE82000580
- Resource Relation:
- Conference: 21. Hanford life sciences symposium on biological availability of trace metals, Richland, WA, USA, 4 Oct 1981
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
GROWTH
SURVIVAL CURVES
NICKEL ARSENIDES
TOXICITY
ACUTE EXPOSURE
BIOLOGICAL AVAILABILITY
CELL CULTURES
EXPERIMENTAL DATA
HAMSTERS
OIL SHALES
PARTICLES
RETORTING
ANIMALS
ARSENIC COMPOUNDS
ARSENIDES
BITUMINOUS MATERIALS
CARBONACEOUS MATERIALS
CHEMICAL REACTIONS
DATA
DECOMPOSITION
ENERGY SOURCES
FOSSIL FUELS
FUELS
INFORMATION
MAMMALS
MATERIALS
NICKEL COMPOUNDS
NUMERICAL DATA
PNICTIDES
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
041000* - Oil Shales & Tar Sands- Environmental Aspects
560301 - Chemicals Metabolism & Toxicology- Cells- (-1987)