Carcinogenesis tests of nickel arsenides, nickel antimonide, and nickel telluride in rats

Journal Article · Sat Jan 01 00:00:00 EST 1983 · Cancer Invest.; (United States)

DOI:https://doi.org/10.3109/07357908309020271· OSTI ID:6133610

Sunderman, Jr, F W; McCully, K S

Carcinogenicity of nickel arsenides (NiAs, Ni/sub 11/As/sub 8/, Ni/sub 5/As/sub 2/, NiAsS), nickel antimonide (NiSb), and nickel telluride (NiTe) was tested by IM administration to male Fischer rats (14 mg Ni/rat). Three negative control groups received similar IM injections of glycerol vehicle, ferronickel alloy (NiFe), or nickel titanate (NiTiO/sub 3/); two positive control groups received nickel oxide (NiO) or ferronickel sulfide (Ni/sub 4/FeS/sub 4/) at equivalent dosages (14 mg Ni/rat). Within 2 years, the incidences of sarcomas at the injection site were: 0/20 (0%) in NiAs-treated rats, 8/16 (50%) in Ni/sub 11/As/sub 8/-treated rats; 17/20 (85%) in Ni/sub 5/As/sub 2/-treated rats; 14/16 (85%) in NiAsS-treated rats; 17/29 (59%) in NiSb-treated rats; and 14/26 (54%) in NiTe-treated rats. No local sarcomas occurred in the negative control groups, including 40 glycerol-treated rats, 16 NiFe-treated rats, and 20 NiTiO/sub 3/-treated rats; in the positive control groups, local sarcomas occurred in 14/15 (93%) of NiO-treated rats and 15/15 (100%) of Ni/sub 4/FeS/sub 4/-treated rats. The 99 sarcomas that were induced by the various nickel compounds included 67 rhabdomyosarcomas, 11 fibrosarcomas, 15 osteosarcomas, 1 fibrous histiocytic sarcoma, and 5 undifferentiated sarcomas; metastases were found in 57 sarcoma-bearing rats. Since Ni/sub 11/As/sub 8/, Ni/sub 5/As/sub 2/, and NiAsS are likely to be formed during oil shale retorting, environmental contamination by nickel arsenides in spent shale products could conceivably pose a carcinogenic hazard if large-scale production of petroleum from oil share is established.

• Research Organization: Univ. of Connecticut School of Medicine, Farmington
• DOE Contract Number: AC02-76EV03140
• OSTI ID: 6133610
• Journal Information: Cancer Invest.; (United States), Vol. 1:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
04 OIL SHALES AND TAR SANDS
ANTIMONY COMPOUNDS
CARCINOGENESIS
NICKEL ARSENIDES
SARCOMAS
DISEASE INCIDENCE
TELLURIUM COMPOUNDS
ENVIRONMENTAL EXPOSURE PATHWAY
OIL SHALES
POLLUTION SOURCES
RATS
RETORTING
ANIMALS
ARSENIC COMPOUNDS
ARSENIDES
BITUMINOUS MATERIALS
CARBONACEOUS MATERIALS
CHEMICAL REACTIONS
DECOMPOSITION
DISEASES
ENERGY SOURCES
FOSSIL FUELS
FUELS
MAMMALS
MATERIALS
NEOPLASMS
NICKEL COMPOUNDS
PATHOGENESIS
PNICTIDES
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
041000 - Oil Shales & Tar Sands- Environmental Aspects