Nuclear medicine technology. Progress report for quarter ending September 30, 1981
A new tellurium fatty acid analog, 15-phenyl-6-(/sup 123m/Te)tellurapentadecanoic acid, was synthesized and evaluated to determine the effect of the terminal phenyl group on myocardial uptake in rats. This new agent shows rapid and pronounced myocardial uptake and unique myocardial retention. The goal of these studies is the development of a tellurium fatty acid labeled with iodine-123 that would be useful to evaluate regional fatty acid metabolism. The /sup 123m/Te-labeled telluraheptadecanoic acid (THDA) analogs 12-THDA and 13-THDA were prepared and evaluated in rats. Both of these analogs show lower heart uptake and significantly decreased heart:blood and heart:lung ratios than the parent compound, 9-THDA. A re-evaluation of 11-(/sup 123m/Te)-THDA indicated that this analog showed significant myocardial uptake analogous to 9-THDA. These results indicate that tellurium in position-12 or -13 of THDA has a special effect on the mechanism of myocardial uptake. Determination of the production yields of /sup 191/Os by neutron irradiation of 97.8% enriched /sup 190/Os has shown that the principal pathway for /sup 190/Os production is via decay of /sup 191m/Os which is produced by the /sup 190/Os n,..gamma.. ..-->.. /sup 191m/Os nuclear reaction. Production yields of /sup 191/Os decrease significantly for irradiation periods beyond 4 to 5 d, suggesting a significant burn-up cross section for /sup 191/Os.Furthermore, irradiations beyond 4 to 5 d result in the rapid increase of /sup 193/Os, /sup 192/Ir, and /sup 194/Ir impurities.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 5244912
- Report Number(s):
- ORNL/TM-8123; ON: DE82011300; TRN: 82-013996
- Country of Publication:
- United States
- Language:
- English
Similar Records
Nuclear medicine progress report, quarter ending September 30, 1983
Nuclear medicine technology progress report for quarter ending December 31, 1980
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARBOXYLIC ACID ESTERS
RADIOPHARMACEUTICALS
MYOCARDIUM
RADIONUCLIDE KINETICS
CHEMICAL PREPARATION
TISSUE DISTRIBUTION
TELLURIUM 123
OSMIUM 190
PRODUCTION
IRIDIUM 191
COORDINATED RESEARCH PROGRAMS
PLATINUM 195
PLATINUM COMPOUNDS
EVALUATION
TIN 117
ANIMALS
BARYON REACTIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
DRUGS
ESTERS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
HADRON REACTIONS
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEI
NUCLEON REACTIONS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OSMIUM ISOTOPES
PLATINUM ISOTOPES
RADIOISOTOPES
RADIOLOGY
RESEARCH PROGRAMS
RODENTS
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
SYNTHESIS
TELLURIUM ISOTOPES
THERAPY
TIN ISOTOPES
TRANSITION ELEMENT COMPOUNDS
USES
VERTEBRATES
YIELDS
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560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)