Transposable Elements Cross Kingdom Boundaries and Contribute to Inflammation and Ageing: Somatic Acquisition of Foreign Transposable Elements as a Catalyst of Genome Instability, Epigenetic Dysregulation, Inflammation, Senescence, and Ageing
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journal
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March 2020 |
Cancer etiology: Variation in cancer risk among tissues is poorly explained by the number of gene mutations
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journal
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February 2018 |
Most gene fusions in cancer are stochastic events
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journal
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March 2019 |
Integrative genomic analysis identifies associations of molecular alterations to APOBEC and BRCA1/2 mutational signatures in breast cancer
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journal
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June 2019 |
Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas: Mutational signature associated with MUTYH deficiency in cancers
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journal
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March 2017 |
Integrative genomic analysis of matched primary and metastatic pediatric osteosarcoma
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journal
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August 2019 |
Nucleotide Excision Repair: From Neurodegeneration to Cancer
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book
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January 2017 |
Genomics and clinical correlates of renal cell carcinoma
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journal
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August 2018 |
Somatic mutations in neurons during aging and neurodegeneration
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journal
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April 2018 |
The role of DNA damage as a therapeutic target in autosomal dominant polycystic kidney disease
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journal
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January 2019 |
The landscape of genomic alterations across childhood cancers
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journal
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February 2018 |
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
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journal
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August 2016 |
Differences between germline and somatic mutation rates in humans and mice
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journal
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May 2017 |
Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors
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journal
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April 2016 |
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
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journal
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May 2016 |
An evolutionary perspective on field cancerization
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journal
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December 2017 |
Clonal evolution of colorectal cancer in IBD
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journal
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February 2017 |
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma
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journal
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January 2019 |
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
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journal
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February 2018 |
The effects of mutational processes and selection on driver mutations across cancer types
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journal
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May 2018 |
Genomic patterns of progression in smoldering multiple myeloma
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journal
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August 2018 |
Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma
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journal
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January 2019 |
Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma
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journal
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April 2019 |
ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma
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journal
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May 2019 |
Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
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journal
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July 2019 |
Genomic landscape and chronological reconstruction of driver events in multiple myeloma
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journal
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August 2019 |
Integrated exome and RNA sequencing of dedifferentiated liposarcoma
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journal
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December 2019 |
Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
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journal
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January 2020 |
The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly
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journal
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January 2020 |
Breast cancer diagnosed during pregnancy is associated with enrichment of non-silent mutations, mismatch repair deficiency signature and mucin mutations
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journal
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August 2018 |
Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours
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journal
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November 2018 |
Intra-tumour diversification in colorectal cancer at the single-cell level
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journal
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April 2018 |
The repertoire of mutational signatures in human cancer
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journal
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February 2020 |
DNA methylation loss in late-replicating domains is linked to mitotic cell division
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journal
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April 2018 |
Detecting the mutational signature of homologous recombination deficiency in clinical samples
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journal
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April 2019 |
The mutational footprints of cancer therapies
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journal
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November 2019 |
Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
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journal
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January 2020 |
Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions
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journal
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January 2019 |
Genomic features of renal cell carcinoma with venous tumor thrombus
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journal
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May 2018 |
Burden of unique and low prevalence somatic mutations correlates with cancer survival
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journal
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March 2019 |
Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues
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journal
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May 2016 |
Integrative genomic analysis of mouse and human hepatocellular carcinoma
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journal
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October 2018 |
Pancreatic cancer organoids recapitulate disease and allow personalized drug screening
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journal
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December 2019 |
Early detection of cancer using circulating tumor DNA: biological, physiological and analytical considerations
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journal
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December 2019 |
Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer
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journal
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June 2017 |
Modeling clinical and molecular covariates of mutational process activity in cancer
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journal
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July 2019 |
Revertant mosaicism repairs skin lesions in a patient with keratitis-ichthyosis-deafness syndrome by second-site mutations in connexin 26
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journal
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February 2017 |
Neutral Theory and the Somatic Evolution of Cancer
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journal
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April 2018 |
Mutations Beget More Mutations—Rapid Evolution of Mutation Rate in Response to the Risk of Runaway Accumulation
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journal
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December 2019 |
Uncovering a unique approach for damaged DNA replication: A computational investigation of a mutagenic tobacco-derived thymine lesion
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journal
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January 2019 |
Germline determinants of the somatic mutation landscape in 2,642 cancer genomes
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posted_content
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November 2017 |
Aging and neurodegeneration are associated with increased mutations in single human neurons
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posted_content
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November 2017 |
BAP1 Loss Predicts Therapeutic Vulnerability in Malignant Peritoneal Mesothelioma
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posted_content
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December 2018 |
De Novo Mutational Signature Discovery in Tumor Genomes using SparseSignatures
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posted_content
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June 2019 |
The Medical Genome Reference Bank: Whole genomes and phenotype of 2,570 healthy elderly
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preprint
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November 2018 |
Mutational analysis of field cancerization in bladder cancer
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posted_content
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January 2019 |
Well-Differentiated Papillary Mesothelioma of the Peritoneum is Genetically Distinct from Malignant Mesothelioma
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posted_content
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July 2019 |
The rate and spectrum of mosaic mutations during embryogenesis revealed by RNA sequencing of 49 tissues
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posted_content
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October 2019 |
An analysis of intrinsic base substitution patterns in diverse species reveals connections to cancer and metabolism
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posted_content
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March 2020 |
Mutation distribution density in tumors reconstructs human’s lost diversity
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posted_content
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September 2019 |
Matching cell lines with cancer type and subtype of origin via mutational, epigenomic and transcriptomic patterns
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posted_content
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October 2019 |
Sequencing Chemically Induced Mutations in the Mutamouse Lacz Reporter Gene Identifies Human Cancer Mutational Signatures
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posted_content
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November 2019 |
APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication
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journal
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January 2016 |
One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin
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journal
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February 2017 |
Molecular and clonal evolution in recurrent metastatic gliosarcoma
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journal
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January 2020 |
Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry
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journal
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March 2017 |
Early divergence of mutational processes in human fetal tissues
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journal
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May 2019 |
DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification
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journal
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February 2017 |
Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors
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journal
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August 2018 |
Somatic mutant clones colonize the human esophagus with age
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journal
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October 2018 |
Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer
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journal
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September 2019 |
Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma
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journal
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March 2019 |
Mutational Signatures in Cancer (MuSiCa): a web application to implement mutational signatures analysis in cancer samples
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journal
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June 2018 |
Relation between DNA ionization potentials, single base substitutions and pathogenic variants
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journal
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July 2019 |
Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing
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journal
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March 2020 |
Utility of circulating tumor DNA in cancer diagnostics with emphasis on early detection
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journal
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October 2018 |
A comprehensive survey of the mutagenic impact of common cancer cytotoxics
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journal
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May 2016 |
Hidden Markov models lead to higher resolution maps of mutation signature activity in cancer
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journal
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July 2019 |
Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer
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journal
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May 2020 |
A comparison of epigenetic mitotic-like clocks for cancer risk prediction
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journal
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June 2020 |
Interpreting the Dependence of Mutation Rates on Age and Time
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journal
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January 2016 |
Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine
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journal
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December 2016 |
Bioactivation mechanisms of N ‐hydroxyaristolactams: Nitroreduction metabolites of aristolochic acids
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journal
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August 2019 |
Turning the tide in myelodysplastic/myeloproliferative neoplasms
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journal
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June 2017 |
High-throughput sequencing of nodal marginal zone lymphomas identifies recurrent BRAF mutations
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journal
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February 2018 |
Assessment of somatic single-nucleotide variation in brain tissue of cases with schizophrenia
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journal
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January 2019 |
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
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journal
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January 2018 |
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors
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journal
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March 2018 |
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
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journal
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September 2018 |
A practical guide for mutational signature analysis in hematological malignancies
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journal
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July 2019 |
Human glioblastoma arises from subventricular zone cells with low-level driver mutations
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journal
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August 2018 |
Tumour lineage shapes BRCA-mediated phenotypes
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journal
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July 2019 |
Mutational processes shape the landscape of TP53 mutations in human cancer
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journal
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September 2018 |
A Simple 3-Parameter Model for Cancer Incidences
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journal
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February 2018 |
Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
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journal
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April 2019 |
Whole-genome sequencing of human malignant mesothelioma tumours and cell lines
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journal
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April 2019 |
Mutational signatures associated with tobacco smoking in human cancer
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posted_content
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May 2016 |
A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data
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posted_content
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June 2017 |
Computational approaches for discovery of mutational signatures in cancer
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posted_content
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June 2017 |
In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors
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posted_content
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December 2017 |
Recapitulation of human germline coding variation in an ultra-mutated infant leukemia
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preprint
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May 2018 |
Reliable analysis of clinical tumor-only whole exome sequencing data
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posted_content
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March 2019 |
Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer
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posted_content
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May 2019 |
Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)
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posted_content
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May 2019 |
Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making
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journal
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April 2018 |
Whole genome sequencing analysis for cancer genomics and precision medicine
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journal
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February 2018 |
The evolutionary history of dogs in the Americas
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July 2018 |
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
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journal
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June 2019 |
APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa
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journal
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August 2018 |
SigsPack, a package for cancer mutational signatures
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September 2019 |
Portrait of a cancer: mutational signature analyses for cancer diagnostics
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May 2019 |
Systems-epigenomics inference of transcription factor activity implicates aryl-hydrocarbon-receptor inactivation as a key event in lung cancer development
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journal
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December 2017 |
Timing somatic events in the evolution of cancer
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journal
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July 2018 |
The rate and spectrum of mosaic mutations during embryogenesis revealed by RNA sequencing of 49 tissues
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journal
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May 2020 |
Medulloblastoma therapy generates risk of a poorly-prognostic H3 wild-type subgroup of diffuse intrinsic pontine glioma: a report from the International DIPG Registry
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journal
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July 2018 |
Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models
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February 2019 |
Somatic mutant clones colonize the human esophagus with age.
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January 2018 |
Genomics and clinical correlates of renal cell carcinoma.
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January 2018 |
The evolutionary history of 2,658 cancers.
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January 2020 |
Cancer Etiology: Variation in Cancer Risk among Tissues is Poorly Explained by the Number of Gene Mutations
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preprint
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August 2017 |
Epigenetic drift, epigenetic clocks and cancer risk
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May 2016 |
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.
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text
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January 2020 |
Single-cell analysis based dissection of clonality in myelofibrosis
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January 2020 |
Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery
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November 2018 |
Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells: Human Somatic Mutation Load and Spectra
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August 2018 |
Mechanisms shaping the mutational landscape of the FRA3B/ FHIT -deficient cancer genome
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November 2018 |
Somatic genome alterations in relation to age in lung adenocarcinoma
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March 2019 |
Nonnegative tensor decomposition with custom clustering for microphase separation of block copolymers
- Alexandrov, Boian S.; Stanev, Valentin G.; Vesselinov, Velimir V.
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https://doi.org/10.1002/sam.11407
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February 2019 |
Tissue-specific mutation accumulation in human adult stem cells during life
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October 2016 |
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours
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journal
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February 2018 |
Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
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journal
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November 2017 |
Integrated analysis of the immunological and genetic status in and across cancer types: impact of mutational signatures beyond tumor mutational burden
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September 2018 |
Discovering novel mutation signatures by latent Dirichlet allocation with variational Bayes inference
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April 2019 |
Understanding mutagenesis through delineation of mutational signatures in human cancer
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May 2016 |
A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data
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journal
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April 2018 |
The genome-wide landscape of C:G > T:A polymorphism at the CpG contexts in the human population
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journal
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March 2020 |
Different mutational characteristics of the subsets of EGFR-tyrosine kinase inhibitor sensitizing mutation-positive lung adenocarcinoma
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journal
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December 2018 |
New insights into the generation and role of de novo mutations in health and disease
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journal
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November 2016 |
Estimating the number of genetic mutations (hits) required for carcinogenesis based on the distribution of somatic mutations
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journal
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March 2019 |
Aging and the rise of somatic cancer-associated mutations in normal tissues
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journal
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January 2018 |
Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma.
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January 2019 |
The repertoire of mutational signatures in human cancer
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January 2020 |
Computational Methods for Characterizing Cancer Mutational Heterogeneity
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June 2017 |
Genomic Alteration Burden in Advanced Prostate Cancer and Therapeutic Implications
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November 2019 |
Interpreting the Dependence of Mutation Rates on Age and Time
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January 2016 |
Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
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journal
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November 2018 |
Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations
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journal
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December 2018 |
The MiAge Calculator: a DNA methylation-based mitotic age calculator of human tissue types
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journal
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February 2018 |
Somatic Mutations and Genome Stability Maintenance in Clonal Coral Colonies
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November 2019 |
Mutations beget more mutations – The baseline mutation rate and runaway accumulation
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July 2019 |
In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors
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journal
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April 2018 |
Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma
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journal
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July 2019 |
Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia
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journal
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January 2020 |
A pilot study of pembrolizumab in smoldering myeloma: report of the clinical, immune, and genomic analysis
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August 2019 |
Correlation of an epigenetic mitotic clock with cancer risk.
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text
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January 2016 |
A practical guide for mutational signature analysis in hematological malignancies.
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January 2019 |
Comprehensive molecular characterization of mitochondrial genomes in human cancers
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January 2020 |
Mutational Analysis of Field Cancerization in Bladder Cancer
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journal
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September 2020 |
Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome
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journal
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April 2017 |
Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity
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journal
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February 2018 |
The effects of mutational processes and selection on driver mutations across cancer types
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June 2017 |
Somatic mutations and genome stability maintenance in clonal coral colonies
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October 2019 |
Aging and neurodegeneration are associated with increased mutations in single human neurons
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journal
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December 2017 |
De novo mutational signature discovery in tumor genomes using SparseSignatures
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journal
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June 2021 |
Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma.
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text
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January 2020 |
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.
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text
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January 2017 |
The evolutionary history of 2,658 cancers.
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text
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January 2020 |
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.
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text
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January 2020 |
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
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journal
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March 2017 |
The mutational footprints of cancer therapies
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posted_content
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June 2019 |
Chromothripsis during telomere crisis is independent of NHEJ, and consistent with a replicative origin
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March 2019 |
Correlation of an epigenetic mitotic clock with cancer risk
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October 2016 |
Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type
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journal
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December 2019 |
Interpreting the dependence of mutation rates on age and time
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preprint
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January 2015 |
Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis
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January 2018 |
Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk
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November 2019 |
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
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April 2018 |
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis
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March 2019 |
Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis
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November 2018 |
Epstein–Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation
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July 2016 |
Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome
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June 2019 |
Epidermal Darwinism and Competitive Equilibrium within the Epidermis
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November 2018 |
Base changes in tumour DNA have the power to reveal the causes and evolution of cancer
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June 2016 |
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
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February 2020 |
Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking
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March 2020 |
Author Correction: The effects of mutational processes and selection on driver mutations across cancer types
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April 2020 |
An alternative model for (breast) cancer predisposition
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April 2017 |
Measuring intratumor heterogeneity by network entropy using RNA-seq data
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November 2016 |
Rational design of non-resistant targeted cancer therapies
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April 2017 |
Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma
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April 2017 |
EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer
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journal
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August 2019 |
The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes
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journal
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May 2017 |
Somatic Variants in the Human Lens Epithelium: A Preliminary Assessment
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journal
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August 2016 |
Single-Cell Analysis Based Dissection of Clonality in Myelofibrosis
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journal
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November 2019 |
A new timepiece: an epigenetic mitotic clock
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journal
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October 2016 |
Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer
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journal
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March 2016 |
The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts
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journal
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October 2016 |
Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations
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journal
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November 2018 |
Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates
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journalarticle
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January 2017 |
The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils.
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journalarticle
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January 2018 |
The ubiquitous ‘cancer mutational signature’ 5 occurs specifically in cancers with deleted FHIT alleles
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journal
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November 2017 |
Somatic genome alterations in relation to age in lung squamous cell carcinoma
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journal
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August 2018 |
DNA Repair Pathway Alterations in Bladder Cancer
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journal
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March 2017 |
Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity
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January 2018 |
5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNA
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journal
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May 2016 |