Development of more efficacious {Tc}-99m organ imaging agents for use in nuclear medicine by analytical characterization of radiopharmaceuticals. Annual technical progress report, September 1, 1992--August 31, 1993
This research program is detailed at development of more efficacious technetium-99m radiopharmaceuticals for use as imaging agents in diagnostic nuclear medicine. We seek to isolate and develop distinct site imaging agents to provide diagnostic information concerning a given pathological condition. Analytical techniques are being developed to enable complete analysis of radiopharmaceutical preparations so that individual complexes can be characterized with respect to imaging efficacy and to enable a radiopharmaceutical to be monitored after injection into a test animal to determine the species that actually accumulates in an organ to provide the image. Administration of the isolated, single most effective imaging complex, rather than a mixture of technetium-containing complexes, wi-11 minimize radiation exposure to the patient and maximize diagnostic information available to the clinician. This report specifically describes the development of capillary electrophoresis (CE) for characterizating diphosphonate skeletal imaging agents. Advances in the development of electrochemical and fiber optic sensors for Tc and Re imaging agents are described. These sensors will ultimately be capable of monitoring a specific chemical state of an imaging agent in vivo after injection into a test animal by implantation in the organ of interest.
- Research Organization:
- Cincinnati Univ., OH (United States). Dept. of Chemistry
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-86ER60487
- OSTI ID:
- 10152407
- Report Number(s):
- DOE/ER/60487-7; ON: DE93014435
- Resource Relation:
- Other Information: PBD: 3 May 1993
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
ELECTROPHORESIS
PHOSPHONATES
TECHNETIUM COMPLEXES
VOLTAMETRY
RHENIUM COMPLEXES
PROGRESS REPORT
RADIOPHARMACEUTICALS
TECHNETIUM 99
FIBER OPTICS
ABSORPTION SPECTROSCOPY
550601
400703
UNSEALED RADIONUCLIDES IN DIAGNOSTICS
RADIOISOTOPE PRODUCTION