Development of more efficacious Tc-99m organ imaging agents for use in nuclear medicine by analytical characterization of radiopharmaceutical mixtures: Progress report, September 1, 1986--August 31, 1989
The long-range objective of this research program is the development of more efficacious technetium-99m radiopharmaceuticals for use as imaging agents in diagnostic nuclear medicine. Within this overall goal, we seek to isolate and develop distinct site imaging agents, each of which has properties optimized to provide diagnostic information concerning a given pathological condition. These objectives are being accomplished by the development of analytical techniques which are capable of separating clinically used radiopharmaceutical mixtures into their component technetium complexes, which can then be characterized in pure form by techniques such as EXAFS and mass spectrometry. The relative imaging efficacies of the individual technetium complexes have been evaluated in animal models to determine if individual components have different in vivo distributions. Techniques are being developed whereby the most efficacious complexes can be prepared rapidly in high yield. Administration of the isolated, single most effective imaging complex, rather than a mixture of technetium-containing complexes (as is the current clinical practice), will minimize radiation exposure to the patient and maximize diagnostic information available to the clinician. 102 refs.
- Research Organization:
- Cincinnati Univ., OH (USA). Dept. of Chemistry
- DOE Contract Number:
- FG02-86ER60487
- OSTI ID:
- 6568613
- Report Number(s):
- DOE/ER/60487-3; ON: DE89006819
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
METABOLITES
LIQUID COLUMN CHROMATOGRAPHY
BOROHYDRIDES
DIAGNOSTIC USES
NUCLEAR MEDICINE
PROGRESS REPORT
RADIOPHARMACEUTICALS
TECHNETIUM 99
TECHNETIUM COMPLEXES
URINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
BORON COMPOUNDS
CHROMATOGRAPHY
COMPLEXES
DOCUMENT TYPES
DRUGS
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
MEDICINE
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
SEPARATION PROCESSES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
USES
WASTES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production