[Mass spectrometric analysis of polycyclic aromatic hydrocarbons adducted to DNA]. Final report

Technical Report · Thu Dec 31 00:00:00 EST 1992

DOI:https://doi.org/10.2172/10112374· OSTI ID:10112374

Barofsky, D F

Studies described herein sought and to synthesize PAH-adducted residues of DNA to serve as models for carrying out the mass spectrometric studies; to construct and test a high performance, pulsed ion bombardment, time-of-flight (TOF) mass spectrometer; to initiate an investigation of the efficacy of using thin wire sample holders to increase sensitivity and focused ion beam bombardment to increase ion yield and ion transmission; and to initiate an investigation of sensitivity enhancing matrices for PAH-adducted DNA.

• Research Organization: Oregon State Univ., Corvallis, OR (United States). Dept. of Agricultural Chemistry
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG06-88ER60696
• OSTI ID: 10112374
• Report Number(s): DOE/ER/60696-5; ON: DE94004850; BR: HA0204030/KP0102000
• Resource Relation: Other Information: PBD: [1992]
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
DNA ADDUCTS
MASS SPECTROSCOPY
MASS SPECTROMETERS
DESIGN
BENZOPYRENE
CHRYSENE
LIQUID COLUMN CHROMATOGRAPHY
EPOXIDES
TIME-OF-FLIGHT METHOD
PROGRESS REPORT
560300
400102
CHEMICALS METABOLISM AND TOXICOLOGY
CHEMICAL AND SPECTRAL PROCEDURES