Inborn anemias in mice. Comprehensive progress report, 1 August 1979-1 June 1982, to accompany twenty-seventh renewal proposal

Technical Report · Thu Jul 01 00:00:00 EDT 1982

OSTI ID:5070592

Bernstein, S E; Russell, E S; Barker, J E

Hereditary anemias of mice have been investigated including four macrocytic anemias, three hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, an ..cap alpha..-thalassemia, and a new target-cell anemia. Each of these blood dyscrasias is caused by the action of a unique mutant gene, which determines the structure of different intracellular molecules controlling a different metabolic process. Thus the wide range of different hereditary anemias has considerable potential for uncovering many different aspects of hemopoietic homeostatic mechanisms in the mouse and by extension to man from an understanding of mammalian mechanisms utilized in the control of erythropoiesis. Each of the different anemias is studied through: (a) biochemical and biophysical characterization of peripheral blood cells; (b) determinations of cellular and organismic radiosensitivity under a variety of conditions; (c) measurements of iron metabolism and heme biosynthesis; (d) morphological and biochemical study of blood-forming tissue; (e) functional tests of the stem cell component; (f) examination of responses to erythroid stimuli and inhibitors; and (g) physiological complementation analysis via transplantation of tissue between individuals of differently affected genotypes.

• Research Organization: Jackson Lab., Bar Harbor, ME (USA)
• DOE Contract Number: AC02-76EV03264
• OSTI ID: 5070592
• Report Number(s): DOE/EV/03264-21; ON: DE82019273
• Resource Relation: Other Information: Portions of document are illegible
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANEMIAS
GENETIC VARIABILITY
HEMATOPOIETIC SYSTEM
BIOLOGICAL FUNCTIONS
HEME
BIOSYNTHESIS
IRON
METABOLISM
BIOCHEMISTRY
BLOOD CELLS
ERYTHROPOIESIS
EXPERIMENTAL DATA
GENE MUTATIONS
HEREDITARY DISEASES
HOMEOSTASIS
MICE
MUTANTS
RADIOSENSITIVITY
STEM CELLS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL VARIABILITY
BLOOD
BLOOD FORMATION
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHEMISTRY
DATA
DISEASES
ELEMENTS
FUNCTIONS
HEMIC DISEASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INFORMATION
MAMMALS
MATERIALS
METALS
MUTATIONS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
RODENTS
SOMATIC CELLS
SYMPTOMS
SYNTHESIS
TRANSITION ELEMENTS
VERTEBRATES
550900* - Pathology
550400 - Genetics
550200 - Biochemistry
551000 - Physiological Systems