Inborn anemias in mice

Technical Report · Mon Jun 01 00:00:00 EDT 1981

OSTI ID:6121812

Bernstein, S E; Barker, J E; Russell, E S

hereditary anemias of mice have been the chief objects of investigation. At present under study are four macrocytic anemias, five hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, an ..cap alpha..-thalassemia, and a new target-cell anemia. Each of these blood dyscrasias is caused by the action of a unique mutant gene, which determines the structure of different intracellular molecules, and thus controls a different metabolic process. Thus our wide range of different hereditary anemias has considerable potential for uncovering many different aspects of hemopoietic homeostatic mechanisms in the mouse. Each anemia is studied through: (a) characterization of peripheral blood values, (b) determinations of radiosensitivity under a variety of conditions, (c) measurements of iron metabolism and heme synthesis, (d) histological and biochemical study of blood-forming tissue, (e) functional tests of the stem cell component, (f) examination of responses to erythroid stimuli, and (g) transplantation of tissue between individuals of differently affected genotypes.

• Research Organization: Jackson Lab., Bar Harbor, ME (USA)
• DOE Contract Number: AS02-76EV03264
• OSTI ID: 6121812
• Report Number(s): DOE/EV/03264-20; ON: DE81029128; TRN: 81-015456
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
RESEARCH PROGRAMS
BLOOD CHEMISTRY
BLOOD FORMATION
HOMEOSTASIS
IRON
METABOLISM
MICE
RADIOSENSITIVITY
TRANSPLANTS
ANIMALS
DISEASES
ELEMENTS
HEMIC DISEASES
MAMMALS
METALS
RODENTS
SYMPTOMS
TRANSITION ELEMENTS
VERTEBRATES
550900* - Pathology
560152 - Radiation Effects on Animals- Animals