Inborn anemias in mice. Progress report, 1 May 1977--31 July 1978
Hereditary anemias of mice have been the chief objects of investigation. At present under study are four macrocytic anemias, four hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, and the autoimmune hemolytic anemia of NZB. Each of these blood dyscrasias is caused by the action of a unique mutant gene, which determines the structure of different intracellular molecules, and thus controls a different metabolic process. Thus our wide range of different hereditary anemias has considerable potential for uncovering many different aspects of hemopoietic homeostatic mechanisms in the mouse. Each anemia is studied through: characterization of peripheral blood values, determinations of radiosensitivity under a variety of conditions, measurements of iron metabolism and heme synthesis, histological and biochemical study of blood-forming tissue, functional tests of the stem cell component, examination of responses to erythroid stimuli, and transplantation of tissue between individuals of differently affected genotypes. Considerable effort is devoted to perfection of hematologic, cell culture, and transplant methods to make these techniques useful in dealing with special problems associated with abnormal function.
- Research Organization:
- Jackson Lab., Bar Harbor, ME (USA)
- DOE Contract Number:
- EY-76-S-02-3264
- OSTI ID:
- 6631804
- Report Number(s):
- COO-3264-17
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANEMIAS
GENETICS
BLOOD
HOMEOSTASIS
RADIOSENSITIVITY
IRON
METABOLISM
BIOSYNTHESIS
GENES
GENOTYPE
HEME
HISTOLOGY
MICE
STEM CELLS
TRANSPLANTS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGY
BODY FLUIDS
CARBOXYLIC ACIDS
DISEASES
ELEMENTS
HEMIC DISEASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
RODENTS
SOMATIC CELLS
SYMPTOMS
SYNTHESIS
TRANSITION ELEMENTS
VERTEBRATES
550400* - Genetics
550200 - Biochemistry