Acridine-intercalator based hypoxia selective cytotoxins

Papadopoulou-Rosenzweig, Maria; Bloomer, William D; Bloomer, William D

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Title: Acridine-intercalator based hypoxia selective cytotoxins

Abstract

Hypoxia selective cytotoxins of the general formula ##STR1## wherein n is from 1 to 5, and NO.sub.2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.

Inventors:

Papadopoulou-Rosenzweig, Maria ^[1]; Bloomer, William D ^[1]; Bloomer, William D ^[1]

Pittsburgh, PA

Issue Date:: Sat Jan 01 00:00:00 EST 1994

Research Org.:: Univ. of Pittsburgh, PA (United States)

OSTI Identifier:: 869193

Patent Number(s):: 5294715

Assignee:: University of Pittsburgh (Pittsburgh, PA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D401/12 - linked by a chain containing hetero atoms as chain links

Show less

DOE Contract Number:: FG02-89ER60869

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: acridine-intercalator; based; hypoxia; selective; cytotoxins; formula; str1; 5-positions; imidazole; compounds; utility; radiosensitizers; chemosensitizers; selective cytotoxins; hypoxia selective; /999/

Citation Formats


                    Papadopoulou-Rosenzweig, Maria, Bloomer, William D, and Bloomer, William D. Acridine-intercalator based hypoxia selective cytotoxins.  United States: N. p., 1994. 
        Web.

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                    Papadopoulou-Rosenzweig, Maria, Bloomer, William D, & Bloomer, William D. Acridine-intercalator based hypoxia selective cytotoxins.  United States.

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                    Papadopoulou-Rosenzweig, Maria, Bloomer, William D, and Bloomer, William D. Sat .  
        "Acridine-intercalator based hypoxia selective cytotoxins".  United States.  https://www.osti.gov/servlets/purl/869193.

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@article{osti_869193,

  title        = {Acridine-intercalator based hypoxia selective cytotoxins},

  author       = {Papadopoulou-Rosenzweig, Maria and Bloomer, William D and Bloomer, William D},

  abstractNote = {Hypoxia selective cytotoxins of the general formula ##STR1## wherein n is from 1 to 5, and NO.sub.2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Sat Jan 01 00:00:00 EST 1994},

  month        = {Sat Jan 01 00:00:00 EST 1994}

}

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Works referenced in this record:

Radiation sensitization and chemopotentiation: Rsu 1069, a compound more efficient than misonidazole in vitro and in vivo
journal, May 1984

Adams, G. E.; Ahmed, I.; Sheldon, P. W.
British Journal of Cancer, Vol. 49, Issue 5
https://doi.org/10.1038/bjc.1984.91

NLA-1 : A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation
journal, January 1992

Denny, William A.; Roberts, Peter B.; Anderson, Robert F.
International Journal of Radiation Oncology*Biology*Physics, Vol. 22, Issue 3
https://doi.org/10.1016/0360-3016(92)90874-H

Carcinoma of the cervix—anaemia, radiotherapy and hyperbaric oxygen
journal, April 1983

Dische, S.; Anderson, P. J.; Sealy, R.
The British Journal of Radiology, Vol. 56, Issue 664
https://doi.org/10.1259/0007-1285-56-664-251

A new ruthenium radiosensitizer: RuC12(DMSO)2(4-Nitroimidazole)2
journal, July 1986

Chan, P. K. L.; Skov, K. A.; James, B. R.
International Journal of Radiation Oncology*Biology*Physics, Vol. 12, Issue 7
https://doi.org/10.1016/0360-3016(86)90225-7

Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508
journal, September 1984

Coleman, C. Norman; Urtasun, Raul C.; Wasserman, Todd H.
International Journal of Radiation Oncology*Biology*Physics, Vol. 10, Issue 9
https://doi.org/10.1016/0360-3016(84)90542-X

Induction of Tumour Hypoxia Post-irradiation: A Method for Increasing the Sensitizing Efficiency of Misonidazole and RSU 1069 in Vivo
journal, January 1989

Stratford, I. J.; Adams, G. E.; Godden, J.
International Journal of Radiation Biology, Vol. 55, Issue 3
https://doi.org/10.1080/09553008914550451

High-Pressure Oxygen and Radiotherapy
journal, May 1955

Davidson, I. Churchill; Sanger, C.; Thomlinson, R. H.
The Lancet, Vol. 265, Issue 6874
https://doi.org/10.1016/S0140-6736(55)90589-4

Binding Mode of 2-amino-5-nitrothiazole (ANT) in Platinum Complexes, Trans -[PtCl ₂ (ANT) ₂ ], Affects DNA Binding, Toxicity and Radiosensitizing Ability
journal, January 1987

Skov, Kirsten A.; Farrell, Nicholas P.
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 52, Issue 2
https://doi.org/10.1080/09553008714551751

Chemotherapy of Cancer
journal, March 1978

Bush, H.
British Journal of Cancer, Vol. 37, Issue 3
https://doi.org/10.1038/bjc.1978.74

Further Studies on Toxic and Radiosensitizing Properties of Ruthenium Complexes of 4-nitroimidazoles
journal, January 1987

Chan, P. K. L.; Skov, K. A.; James, B. R.
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 52, Issue 1
https://doi.org/10.1080/09553008714551471

Radiosensitization of mammalian cells by transition metal complexes containing nitroimidazole ligands
journal, August 1984

Chibber, R.; Stratford, I. J.; Ahmed, I.
International Journal of Radiation Oncology*Biology*Physics, Vol. 10, Issue 8
https://doi.org/10.1016/0360-3016(84)90320-1

Reductive metabolism and hypoxia-selective toxicity of nitracrine
journal, July 1986

Wilson, William R.; Denny, William A.; Stewart, Georgina M.
International Journal of Radiation Oncology*Biology*Physics, Vol. 12, Issue 7
https://doi.org/10.1016/0360-3016(86)90266-X

Hypoxia-selective Radiosensitization of Mammalian Cells by Nitracrine, an Electron-affinic DNA Intercalator
journal, January 1987

Roberts, Peter B.; Anderson, Robert F.; Wilson, William R.
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 51, Issue 4
https://doi.org/10.1080/09553008414552171

Enhancement of chemotherapy agents
journal, March 1982

McNally, N. J.
International Journal of Radiation Oncology*Biology*Physics, Vol. 8, Issue 3-4
https://doi.org/10.1016/0360-3016(82)90691-5

The clinical testing of Ro 03-8799—Pharmacokinetics, toxicology, tissue and tumor concentrations
journal, September 1984

Saunders, Michele I.; Anderson, Peter J.; Bennett, Michael H.
International Journal of Radiation Oncology*Biology*Physics, Vol. 10, Issue 9
https://doi.org/10.1016/0360-3016(84)90544-3

A phase I study of the hypoxic cell radiosensitizer Ro-03-8799
journal, September 1984

Roberts, J. T.; Bleehen, N. M.; Workman, P.
International Journal of Radiation Oncology*Biology*Physics, Vol. 10, Issue 9
https://doi.org/10.1016/0360-3016(84)90543-1

Analogues of RSU-1069: Radiosensitization and toxicity in vitro and in vivo
journal, July 1986

Ahmed, I.; Jenkins, T. C.; Walling, J. M.
International Journal of Radiation Oncology*Biology*Physics, Vol. 12, Issue 7
https://doi.org/10.1016/0360-3016(86)90230-0

Role of Oxygen in Modifying the Radiosensitivity of E. Coli B.
journal, November 1956

Alper, Tikvah; Howard-Flanders, P.
Nature, Vol. 178, Issue 4540
https://doi.org/10.1038/178978a0

Third International Meeting on Progress in Radio-Oncology
journal, January 1985

Fowler, J. F.
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 48, Issue 3
https://doi.org/10.1080/09553008514551461

The Radiation Chemistry of Some Platinum-Containing Radiosensitizers and Related Compounds
journal, April 1985

Butler, John; Hoey, Brigid M.; Swallow, A. John
Radiation Research, Vol. 102, Issue 1
https://doi.org/10.2307/3576425

NLP-1: A DNA intercalating hypoxic cell radiosensitizer and cytotoxin
journal, April 1989

Panicucci, R.; Heal, R.; Laderoute, K.
International Journal of Radiation Oncology*Biology*Physics, Vol. 16, Issue 4
https://doi.org/10.1016/0360-3016(89)90911-5

Selective toxicity of nitracrine to hypoxic mammalian cells
journal, February 1984

Wilson, W. R.; Denny, W. A.; Twigden, S. J.
British Journal of Cancer, Vol. 49, Issue 2
https://doi.org/10.1038/bjc.1984.34

Radiation and Platinum Drug Interaction
journal, January 1985

Nias, A. H. W.
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 48, Issue 3
https://doi.org/10.1080/09553008514551301

The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay
journal, April 1989

Stratford, Ian J.; Stephens, Miriam A.
International Journal of Radiation Oncology*Biology*Physics, Vol. 16, Issue 4
https://doi.org/10.1016/0360-3016(89)90898-5

Radiosensitization of Mammalian Cells in Vitro by Nitroacridines
journal, August 1990

Roberts, Peter B.; Denny, William A.; Wakelin, Laurence P. G.
Radiation Research, Vol. 123, Issue 2
https://doi.org/10.2307/3577539

Radiosensitization of EMT6 cells by four platinum complexes
journal, May 1985

Teicher, Beverly A.; Rockwell, Sara; Lee, Jonathan B.
International Journal of Radiation Oncology*Biology*Physics, Vol. 11, Issue 5
https://doi.org/10.1016/0360-3016(85)90116-6

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Similar Records

Title: Acridine-intercalator based hypoxia selective cytotoxins

Abstract

Citation Formats

Radiation sensitization and chemopotentiation: Rsu 1069, a compound more efficient than misonidazole in vitro and in vivo journal, May 1984

NLA-1 : A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation journal, January 1992

Carcinoma of the cervix—anaemia, radiotherapy and hyperbaric oxygen journal, April 1983

A new ruthenium radiosensitizer: RuC12(DMSO)2(4-Nitroimidazole)2 journal, July 1986

Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508 journal, September 1984

Induction of Tumour Hypoxia Post-irradiation: A Method for Increasing the Sensitizing Efficiency of Misonidazole and RSU 1069 in Vivo journal, January 1989

High-Pressure Oxygen and Radiotherapy journal, May 1955

Binding Mode of 2-amino-5-nitrothiazole (ANT) in Platinum Complexes, Trans -[PtCl 2 (ANT) 2 ], Affects DNA Binding, Toxicity and Radiosensitizing Ability journal, January 1987

Chemotherapy of Cancer journal, March 1978

Further Studies on Toxic and Radiosensitizing Properties of Ruthenium Complexes of 4-nitroimidazoles journal, January 1987

Radiosensitization of mammalian cells by transition metal complexes containing nitroimidazole ligands journal, August 1984

Reductive metabolism and hypoxia-selective toxicity of nitracrine journal, July 1986

Hypoxia-selective Radiosensitization of Mammalian Cells by Nitracrine, an Electron-affinic DNA Intercalator journal, January 1987

Enhancement of chemotherapy agents journal, March 1982

The clinical testing of Ro 03-8799—Pharmacokinetics, toxicology, tissue and tumor concentrations journal, September 1984

A phase I study of the hypoxic cell radiosensitizer Ro-03-8799 journal, September 1984

Analogues of RSU-1069: Radiosensitization and toxicity in vitro and in vivo journal, July 1986

Role of Oxygen in Modifying the Radiosensitivity of E. Coli B. journal, November 1956

Third International Meeting on Progress in Radio-Oncology journal, January 1985

The Radiation Chemistry of Some Platinum-Containing Radiosensitizers and Related Compounds journal, April 1985

NLP-1: A DNA intercalating hypoxic cell radiosensitizer and cytotoxin journal, April 1989

Selective toxicity of nitracrine to hypoxic mammalian cells journal, February 1984

Radiation and Platinum Drug Interaction journal, January 1985

The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay journal, April 1989

Radiosensitization of Mammalian Cells in Vitro by Nitroacridines journal, August 1990

Radiosensitization of EMT6 cells by four platinum complexes journal, May 1985

Radiation sensitization and chemopotentiation: Rsu 1069, a compound more efficient than misonidazole in vitro and in vivo
journal, May 1984

NLA-1 : A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation
journal, January 1992

Carcinoma of the cervix—anaemia, radiotherapy and hyperbaric oxygen
journal, April 1983

A new ruthenium radiosensitizer: RuC12(DMSO)2(4-Nitroimidazole)2
journal, July 1986

Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508
journal, September 1984

Induction of Tumour Hypoxia Post-irradiation: A Method for Increasing the Sensitizing Efficiency of Misonidazole and RSU 1069 in Vivo
journal, January 1989

High-Pressure Oxygen and Radiotherapy
journal, May 1955

Binding Mode of 2-amino-5-nitrothiazole (ANT) in Platinum Complexes, Trans -[PtCl ₂ (ANT) ₂ ], Affects DNA Binding, Toxicity and Radiosensitizing Ability
journal, January 1987

Chemotherapy of Cancer
journal, March 1978

Further Studies on Toxic and Radiosensitizing Properties of Ruthenium Complexes of 4-nitroimidazoles
journal, January 1987

Radiosensitization of mammalian cells by transition metal complexes containing nitroimidazole ligands
journal, August 1984

Reductive metabolism and hypoxia-selective toxicity of nitracrine
journal, July 1986

Hypoxia-selective Radiosensitization of Mammalian Cells by Nitracrine, an Electron-affinic DNA Intercalator
journal, January 1987

Enhancement of chemotherapy agents
journal, March 1982

The clinical testing of Ro 03-8799—Pharmacokinetics, toxicology, tissue and tumor concentrations
journal, September 1984

A phase I study of the hypoxic cell radiosensitizer Ro-03-8799
journal, September 1984

Analogues of RSU-1069: Radiosensitization and toxicity in vitro and in vivo
journal, July 1986

Role of Oxygen in Modifying the Radiosensitivity of E. Coli B.
journal, November 1956

Third International Meeting on Progress in Radio-Oncology
journal, January 1985

The Radiation Chemistry of Some Platinum-Containing Radiosensitizers and Related Compounds
journal, April 1985

NLP-1: A DNA intercalating hypoxic cell radiosensitizer and cytotoxin
journal, April 1989

Selective toxicity of nitracrine to hypoxic mammalian cells
journal, February 1984

Radiation and Platinum Drug Interaction
journal, January 1985

The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay
journal, April 1989

Radiosensitization of Mammalian Cells in Vitro by Nitroacridines
journal, August 1990

Radiosensitization of EMT6 cells by four platinum complexes
journal, May 1985