Title: Transgenic rabbit that expresses a functional human lipoprotein (a)

Abstract

A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.

Inventors:

Rouy, Didier ^[1]; Duverger, Nicolas ^[2]; Emmanuel, Florence ^[3]; Denefle, Patrice ^[4]; Houdebine, Louis-Marie ^[5]; Viglietta, Celine ^[6]; Rubin, Edward M ^[7]; Hughes, Steven D ^[8]

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+ Show Inventor Affiliations

1. Thiais, FR
2. Paris, FR
3. Aubervilliers, FR
4. Saint Maur, FR
5. Buc, FR
6. Versailles, FR
7. Berkeley, CA
8. Oakland, CA

Issue Date:

Wed Jan 01 00:00:00 EST 2003

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

OSTI Identifier:

875011

Patent Number(s):

6512161

Assignee:

Aventis Pharmaceuticals, Inc. (Bridgewater, NJ)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY

A01K2207/15 - Humanized animals
A01K2217/00 - Genetically modified animals
A01K2217/05 - Animals comprising random inserted nucleic acids
A01K2227/107 - Rabbit
A01K2267/03 - Animal model, e.g. for test or diseases
A01K2267/0375 - Animal model for cardiovascular diseases
A01K67/0275 - {Genetically modified vertebrates, e.g. transgenic}
A01K67/0278 - {Humanized animals, e.g. knockin}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K49/0008 - {Screening agents using

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P3/06 - Antihyperlipidemics
A61P43/00 - Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P7/02 - Antithrombotic agents
A61P9/06 - Antiarrhythmics
A61P9/10 - for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/775 - Apolipopeptides

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N15/8509 - {for producing genetically modified animals, e.g. transgenic}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S977/924 - using nanostructure as support of dna analysis

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DOE Contract Number:  

AC03-76SF00098

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

transgenic; rabbit; expresses; functional; human; lipoprotein; genomic; dna; sequences; encode; apolipoprotein; polypeptides; capable; combining; produce; process; creating; identify; compounds; effective; treatment; diseases; associated; induced; andor; exacerbated; lpa; expression; dna sequence; /800/