Inhibition of selectin binding
Abstract
This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, these composition scan be used to palliate certain inflammatory and immunological conditions.
- Inventors:
-
- Rodeo, CA
- Albany, CA
- New Delhi, IN
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 874039
- Patent Number(s):
- 6299897
- Application Number:
- 09/440880
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- inhibition; selectin; binding; provides; compositions; inhibiting; cells; expressing; p-; l-selectin; surface; corresponding; ligand; covalently; crosslinked; lipid; composition; prepared; saccharides; acidic; separate; lipids; interposed; inhibit; achieved; effective; oligosaccharide; concentration; 10; fold; below; free; saccharide; selectins; involved; recruiting; sites; injury; scan; palliate; inflammatory; immunological; conditions; recruiting cells; provides compositions; selectin binding; separate lipids; oligosaccharide concentration; expressing p-; fold below; free saccharide; lipid composition; effective oligosaccharide; covalently crosslinked; crosslinked lipid; corresponding ligand; immunological conditions; inhibit binding; /424/514/999/
Citation Formats
Nagy, Jon O, Spevak, Wayne R, Dasgupta, Falguni, and Bertozzi, Caroline. Inhibition of selectin binding. United States: N. p., 2001.
Web.
Nagy, Jon O, Spevak, Wayne R, Dasgupta, Falguni, & Bertozzi, Caroline. Inhibition of selectin binding. United States.
Nagy, Jon O, Spevak, Wayne R, Dasgupta, Falguni, and Bertozzi, Caroline. Mon .
"Inhibition of selectin binding". United States. https://www.osti.gov/servlets/purl/874039.
@article{osti_874039,
title = {Inhibition of selectin binding},
author = {Nagy, Jon O and Spevak, Wayne R and Dasgupta, Falguni and Bertozzi, Caroline},
abstractNote = {This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, these composition scan be used to palliate certain inflammatory and immunological conditions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2001},
month = {Mon Jan 01 00:00:00 EST 2001}
}
Works referenced in this record:
Preparation and Characterization of Polymerized Liposomes
journal, June 1985
- O'Brien, David F.; Klingbiel, Richard T.; Specht, Donald P.
- Annals of the New York Academy of Sciences, Vol. 446, Issue 1 Macromolecule
Direct colorimetric detection of a receptor-ligand interaction by a polymerized bilayer assembly
journal, July 1993
- Charych, D.; Nagy, J.; Spevak, W.
- Science, Vol. 261, Issue 5121
Polymerized liposomes containing C-glycosides of sialic acid: potent inhibitors of influenza virus in vitro infectivity
journal, February 1993
- Spevak, Wayne; Nagy, Jon O.; Charych, Deborah H.
- Journal of the American Chemical Society, Vol. 115, Issue 3
Molecular assemblies of functionalized polydiacetylenes
journal, January 1995
- Spevak, Wayne; Nagy, Jon O.; Charych, Deborah H.
- Advanced Materials, Vol. 7, Issue 1
Studies on carbohydrate-binding proteins using liposome-based systems—I. Preparation of neoglycoprotein-conjugated liposomes and the feasibility of their use as drug-targeting devices
journal, January 1992
- Noboru, Yamazaki; Shuji, Kojima; Gabius, Sigrun
- International Journal of Biochemistry, Vol. 24, Issue 1
[6] Neoglycoprotein-liposome and lectin-liposome conjugates as tools for carbohydrate recognition research
book, January 1994
- Yamazaki, Noboru; Kodama, Makoto; Gabius, Hans-Joachim
- Neoglycoconjugates Part A: Synthesis, p. 56-65
Polydiacetylene monolayers functionalized with amino acids
journal, October 1992
- Wilson, Troy E.; Bednarski, Mark D.
- Langmuir, Vol. 8, Issue 10
Cardioprotection by liposome-conjugated sialyl Lewisx-oligosaccharide in myocardial ischaemia and reperfusion injury
journal, December 1995
- Murohara, T.
- Cardiovascular Research, Vol. 30, Issue 6
Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.
journal, December 1991
- Papahadjopoulos, D.; Allen, T. M.; Gabizon, A.
- Proceedings of the National Academy of Sciences, Vol. 88, Issue 24