Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy
Abstract
The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.
- Inventors:
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175518
- Patent Number(s):
- 6951640
- Application Number:
- 10/375,454
- Assignee:
- Brookhaven Science Associates, LLC (Upton, NY)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC02-98CH10886
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Miura, Michiko, and Slatkin, Daniel N. Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy. United States: N. p., 2005.
Web.
Miura, Michiko, & Slatkin, Daniel N. Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy. United States.
Miura, Michiko, and Slatkin, Daniel N. Tue .
"Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy". United States. https://www.osti.gov/servlets/purl/1175518.
@article{osti_1175518,
title = {Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy},
author = {Miura, Michiko and Slatkin, Daniel N.},
abstractNote = {The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 04 00:00:00 EDT 2005},
month = {Tue Oct 04 00:00:00 EDT 2005}
}
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