Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
Abstract
Cyclo agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N,N,N',N'-tetra acetic acid.
- Inventors:
-
- Coram, NY
- Stony Brook, NY
- Setauket, NY
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 869181
- Patent Number(s):
- 5292938
- Assignee:
- Associated Universities, Inc. (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- synthesis; 4-substituted-trans-1; 2-diaminocyclohexyl; polyaminocarboxylate; metal; chelating; agents; preparation; stable; radiometal; antibody; immunoconjugates; therapy; spect; pet; imaging; cyclo; useful; forming; antibody-metal; conjugates; diagnostic; therapeutic; purposes; compounds; processes; disclosed; including; 4-haloacetamido-trans-1; 4-isothiocyanato-trans-1; 2-diamino; cyclohexane-n; -tetra; acetic; acid; therapeutic purposes; metal chelating; stable radiometal; radiometal antibody; acetic acid; chelating agents; chelating agent; disclosed including; pet imaging; antibody immunoconjugates; agents useful; cyclohexyl polyaminocarboxylate; forming antibody-metal; polyaminocarboxylate metal; /999/530/
Citation Formats
Mease, Ronnie C, Mausner, Leonard F, and Srivastava, Suresh C. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging. United States: N. p., 1994.
Web.
Mease, Ronnie C, Mausner, Leonard F, & Srivastava, Suresh C. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging. United States.
Mease, Ronnie C, Mausner, Leonard F, and Srivastava, Suresh C. Sat .
"Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging". United States. https://www.osti.gov/servlets/purl/869181.
@article{osti_869181,
title = {Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging},
author = {Mease, Ronnie C and Mausner, Leonard F and Srivastava, Suresh C},
abstractNote = {Cyclo agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N,N,N',N'-tetra acetic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1994},
month = {Sat Jan 01 00:00:00 EST 1994}
}
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Works referenced in this record:
Stereocontrolled syntheses for the six diastereomeric 1,2-dihydroxy-4,5-diaminocyclohexanes: PtII complexes and P-388 antitumor properties
journal, August 1987
- Witiak, Donald T.; Rotella, David P.; Filippi, Joyce A.
- Journal of Medicinal Chemistry, Vol. 30, Issue 8