Synthetic Nano-Low Density Lipoprotein as Targeted Drug DeliveryVehicle for Glioblastoma Multiforme
Journal Article
·
· International Journal of Pharmaceutics
OSTI ID:923003
This paper discribes a synthetic low density lipoprotein(LDL) made by complexing a 29 amino acid that consists of a lipid bindingdomain and the LDL receptor binding domain with a lipid microemulsion.The nano-LDL particles were intermdiate in size between LDL and HDL andbound to LDL receptors on GBM brain tumor cells. Synthetic nano-LDLuptake by GBM cells was LDL receptor specific and dependent on cellreceptor number. It is suggested that these synthetic particles can serveas a delivery vehicle for hydophobic anti-tumor drugs by targeting theLDL receptor.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Director. Office of Science. Biological andEnvironmental Research
- DOE Contract Number:
- DE-AC02-05CH11231
- OSTI ID:
- 923003
- Report Number(s):
- LBNL-60496; IJPHDE; R&D Project: 440Z01; BnR: KP1102020; TRN: US200804%%834
- Journal Information:
- International Journal of Pharmaceutics, Vol. 328, Issue 1; Related Information: Journal Publication Date: 07/31/2006; ISSN 0378-5173
- Country of Publication:
- United States
- Language:
- English
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