Interactions of 1D- and 2D-layered inorganic nanoparticles with fibroblasts and human mesenchymal stem cells
- Stony Brook Univ., Stony Brook, NY (United States). Dept. of Biomedical Engineering
Here, this study investigates the effects of tungsten disulfide nanotubes (WSNTs) and molybdenum disulfide nanoplatelets (MSNPs) on fibroblasts (NIH-3T3) and mesenchymal stem cells (MSCs) to determine safe dosages for potential biomedical applications. Cytotoxicity of MSNPs and WSNTs (5–300 μg/ml) on NIH-3T3 and MSCs was assessed at 6, 12 or 24 h. MSC differentiation to adipocytes and osteoblasts was assessed following treatment for 24 h. Only NIH-3T3 cells treated with MSNPs showed dose or time dependent increase in cytotoxicity. Differentiation markers of MSCs in treated groups were unaffected compared with untreated controls. In conclusion, MSNPs and WSNTs at concentrations less than 50 μg/ml are potentially safe for treatment of fibroblasts or MSCs for up to 24 h.
- Research Organization:
- Stony Brook Univ., NY (United States)
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- AC02-98CH10886; 1DP2OD007394-01
- OSTI ID:
- 1345589
- Journal Information:
- Nanomedicine, Vol. 10, Issue 11; ISSN 1743-5889
- Publisher:
- Future MedicineCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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journal | August 2017 |
Comparative Effects of Graphene and Molybdenum Disulfide on Human Macrophage Toxicity
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journal | August 2020 |
Short Pulse Laser Synthesis of Transition-Metal Dichalcogenide Nanostructures under Ambient Conditions
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journal | June 2017 |
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