Bacterial production of methyl ketones

Beller, Harry R.; Goh, Ee-Been

Title: Bacterial production of methyl ketones

Patent · Tue Jan 31 00:00:00 EST 2017

OSTI ID:1342098

Beller, Harry R.; Goh, Ee-Been

The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces .beta.-ketoacyl-CoAs through a re-engineered .beta.-oxidation pathway and overexpresses FadM.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California

Patent Number(s):: 9,556,458

Application Number:: 14/354,510

OSTI ID:: 1342098

Resource Relation:: Patent File Date: 2012 Oct 26

Country of Publication:: United States

Language:: English

References (6)

Production of fatty acid esters Sanchez-Riera, Fernando; Del Cardayre, Stephen; Valle, Fernando https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100274033 US Patent Application 12/768419; 20100274033	patent-application	October 2010
Fatty Acid-Producing Hosts Pfleger, Brian F.; Lennen, Rebecca M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110165637 US Patent Document 12/984343; 20110165637	patent	July 2011
Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals Dellomonaco, Clementina; Clomburg, James M.; Miller, Elliot N. Nature, Vol. 476, Issue 7360, p. 355-359 https://doi.org/10.1038/nature10333	journal	August 2011
Identification of Î²-oxidation and thioesterase activities inStaphylococcus carnosus833 strain Engelvin, G.; Feron, G.; Perrin, C. FEMS Microbiology Letters, Vol. 190, Issue 1 https://doi.org/10.1111/j.1574-6968.2000.tb09272.x	journal	September 2000
Substantial improvements in methyl ketone production in E. coli and insights on the pathway from in vitro studies Goh, Ee-Been; Baidoo, Edward E. K.; Burd, Helcio Metabolic Engineering, Vol. 26 https://doi.org/10.1016/j.ymben.2014.09.003	journal	November 2014
Synthesis of methyl ketones by metabolically engineered Escherichia coli Park, John; Rodríguez-Moyá, María; Li, Mai Journal of Industrial Microbiology & Biotechnology, Vol. 39, Issue 11, p. 1703-1712 https://doi.org/10.1007/s10295-012-1178-x	journal	August 2012

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Title: Bacterial production of methyl ketones

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